Results 201 to 210 of about 53,675 (256)

Hierarchical Twin Networks Enable Exceptional Strength and Fracture Toughness in Titanium

open access: yesAdvanced Science, EarlyView.
A commercial‐purity titanium with hierarchical ultrafine twin structures delivers an exceptional combination of fracture toughness (KJIc) of 187 MPa·m1/2 and specific yield strength of 140 MPa·cm3·g−1, in which pre‐engineered high‐density twin boundaries stimulate massive and dislocations to blunt crack tip.
Xiao‐Wei Zou  
+3 more
wiley   +1 more source

Dislocation‐Mediated Lattice Distortion and Griffiths Phase Behavior in Melt‐Spun Ni2MnSb Ribbons

open access: yesAdvanced Science, EarlyView.
This figure illustrates how melt‐spinning introduces dislocations into Ni2MnSb Heusler alloys. TEM images reveal local lattice distortions and associated strain fields surrounding dislocations at a representative wheel speed. As wheel speed increases, these distortions promote the formation of ferromagnetic clusters within a paramagnetic matrix ...
Kun Wang   +11 more
wiley   +1 more source

PhosSight: A Unified Deep Learning Framework Boosting and Accelerating Phosphoproteome Identification to Enable Biological Discoveries

open access: yesAdvanced Science, EarlyView.
PhosSight is a unified deep‐learning framework for phosphoproteome identification, featured by a phosphorylation‐aware detectability predictor. It improves identification sensitivity in DDA through deep re‐localization and rescoring, accelerates DIA searches by detectability‐guided spectral library pruning, and expands phosphoproteome coverage to ...
Ben Wang   +10 more
wiley   +1 more source

Stem Cell Differentiation Disperses Transcriptional Clusters via a Conserved Surface‐Condensate Trajectory

open access: yesAdvanced Science, EarlyView.
Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity disperses them. This work reveals how biophysical forces at enhancer surfaces dynamically build and dismantle stem cell transcription hubs, reshaping cell ...
Tim Klingberg   +18 more
wiley   +1 more source

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

open access: yesAdvanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li   +14 more
wiley   +1 more source

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