Results 61 to 70 of about 189,287 (283)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Global landslide mapping using U-Net architecture with diverse backbones across multi-regional and multi-sensor remote sensing datasets

Frontiers in Earth Science
Landslides remain a constant hazard to societies in hilly regions worldwide, necessitating accurate and scalable detection techniques. In this study, we assess the performance of cutting-edge deep learning architecture, specifically U-Net, combined with ...
Naveen Chandra, Naveen Chandra, Himadri Vaidya, Himadri Vaidya, Kumar Abhinav, Sansar Raj Meena, Sansar Raj Meena   +6 more
doaj   +1 more source

Assessing model of highway slope stability based on optimized SVM

China Geology, 2020
: Considering the geological hazards attributed to the highway slope, using a common simple model cannot accurately assess the stability of the slope.
Peng-fei Niu, Ai-hong Zhou, Hu-cheng Huang   +2 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Regulation of open pit slope stability in Russia [PDF]

, 2020
Alexander Makarov, I. S. Livinsky, Victor Spirin, А. А. Павлович   +3 more
openalex   +1 more source

Spatially Variable Coal Slope Stability Analysis using Image-Based Scaled Boundary Finite Element Method [PDF]

, 2022
Dakshith Ruvin Wijesinghe, Ashley P. Dyson, G. You, M. Khandelwal, E. Ooi   +4 more
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Three-Dimensional Analysis of Complex Rock Slope Stability Affected by Fault and Weak Layer Based on FESRM

Advances in Civil Engineering, 2019
Slope stability analysis is the most important problem in slope engineering design and construction. Open-pit slope often spans several strata, many of which are relatively weak. There may be faults and weak layers across the whole rock.
Yang Li, Ling Yu, Weidong Song, Tianhong Yang   +3 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source