Results 91 to 100 of about 768,167 (327)

Probabilistic stability assessment of slope considering soft soil and silty clay foundations

Scientific Reports
Although deterministic analysis can provide initial insights into slope stability, there is no way to reflect the true distribution of soil properties within a slope. To further investigate the effects of the spatial variability of soil properties on the
Gan Liu, Dongxian Li
doaj   +1 more source

Slope stability analysis in Ulubelu Lampung using computational analysis program

Civil and Environmental Science Journal, 2020
Ulubelu sub-district is the center of geothermal activity in Lampung Province. The Ulubelu geothermal project supply 25% of electricity to Lampung Province.
M. Jafri, Iswan Iswan, M. Rizki, G.E. Susilo   +3 more
doaj   +1 more source

Stratified slopes, numerical and empirical stability analysis [PDF]

, 2018
Urbanisation means that many natural slopes in and around cities are often subjected to cuts resulting in dramatic changes in the geometry of slope faces mostly by increasing slope angle which could lead to failures with catastrophic consequences.
Alireza Ahangar-Asr, Brinkgreve R, Bromhead EN, Rémi Sauffisseau, Smith MJ, USGS (U.S. Geological Survey), Vermeer P, Wu JJ   +7 more
core   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Evaluasi Kelongsoran Pada Ruas Jalan Weleri – Sukorejo Km. 55 Kab. Kendal [PDF]

, 2013
This undergraduate thesis is about the stability of slopes on Weleri roads, mechanisms and mitigation in Weleri – Sukorejo roads, Kendal Regency. The road was built to support economic growth in Weleri and its surroundings.
Alfanto, G. (Galieh), Apriatmoko, Y. (Yusni), Atmanto, I. D. (Indrastono), Pardoyo, B. (Bambang)   +3 more
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Three-Dimensional Analysis of Complex Rock Slope Stability Affected by Fault and Weak Layer Based on FESRM

Advances in Civil Engineering, 2019
Slope stability analysis is the most important problem in slope engineering design and construction. Open-pit slope often spans several strata, many of which are relatively weak. There may be faults and weak layers across the whole rock.
Yang Li, Ling Yu, Weidong Song, Tianhong Yang   +3 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Slope Instability of the Earthen Levee in Boston, UK: Numerical Simulation and Sensor Data Analysis

, 2014
The paper presents a slope stability analysis for a heterogeneous earthen levee in Boston, UK, which is prone to occasional slope failures under tidal loads.
Jordan, D., Krzhizhanovskaya, V. V., Melnikova, N. B., Sloot, P. M. A.   +3 more
core   +1 more source