Results 101 to 110 of about 768,167 (327)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Analysis of Vegetation Effects on Slope Stability of Embankment [PDF]

, 2020
Md. Murad Hasan, Mehejabin Chowdhury Ankan   +1 more
openalex   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Correlations between factor of safety with distributed load and crest length – Zariwam landslide as case study

Geology, Ecology, and Landscapes
This paper examines the impact on Factor of Safety (FS) value due to the variation in distributed load (LD), Crest length (CL), shear strength (τ), and shear stress (σ) both in seismic and non-seismic conditions.
Muhammad Israr Khan
doaj   +1 more source

Linear stability analysis of rapid granular flow on a slope and density wave formation

, 2003
The linear stability of rapid granular flow on a slope under gravity against the longitudinal perturbation is analyzed using hydrodynamic equations. It is demonstrated that the steady flow uniform along the flow direction becomes unstable against the ...
Mitarai, Namiko, Nakanishi, Hiizu
core   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Slope stability analysis considering the strength anisotropy of c-φ soil. [PDF]

Sci Rep, 2022
He Y, Li Z, Wang W, Yuan R, Zhao X, Nikitas N.   +5 more
europepmc   +1 more source

Overburden Dump Slope Stability: A Case Study At Coal Mine [PDF]

, 2013
Slope stability of overburden dumps plays as integral part of opencast mine project throughout the operation process. Waste dumps always have steep angled slopes as the waste has been tipped over from the top of the dump in a continuous and progressive ...
Mahapatro, Sudeep, Rai , Purna Bahadur
core  

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source