Results 81 to 90 of about 768,167 (327)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Spatiotemporal analyses of soil moisture from point to footprint scale in two different hydroclimatic regions [PDF]

, 2011
This paper presents time stability analyses of soil moisture at different spatial measurement support scales (point scale and airborne remote sensing (RS) footprint scale 800 m × 800 m) in two different hydroclimatic regions.
Ines, Amor V. M., Jacobs, Jennifer M., Joshi, Champa, Mohanty, Binayak P.   +3 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Analysis of slope failure at Maran highway using slope/w software [PDF]

, 2011
Analysis towards certain slope at Malaysia is important due to many tragedy occurred effect by the slope failure. The purpose of this study is to analyze the slope stability at KM 99 and 101, Maran Highway that carried out by using computer simulation ...
Annas Robani, Aminudin
core  

Upsilon \bar BB$ Couplings, Slope of the Isgur-Wise Function and Improved Estimate of \boldmath{$V_{cb}$}}

, 1994
We estimate the sum of the $\Upsilon \bar BB $ couplings using QCD Spectral Sum Rules (QSSR). Our result implies the phenomenological bound $\xi'(vv'=1) \geq -1.04$ for the slope of the Isgur-Wise function. An analytic estimate of the (physical) slope to
Albrecht, Albrecht, Alexandrou, Ali, Bagan, Bagan, Bagan, Baier, Ball, Ball, Bjorken, Blok, Carlson, Crawford, Crawford, Danilov, de Rafael, de Rafael, Dominquez, Falk, Falk, Georgi, Grinstein, Isgur, Isgur, Luke, Maiani, Mannel, Martinelli, Narison, Narison, Narison, Narison, Narison, Narison, Narison, Narison, Narison, Narison, Neubert, Neubert, Neubert, Ovchinnikov, S. Narison, Sachrajda, Sharpe   +45 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Probability analysis of undrained clay slope stability considering strength anisotropy and heterogeneous rotated anisotropy

Frontiers in Earth Science
Strength anisotropy and heterogeneous rotated anisotropy are prevalent phenomena in natural slopes. Previous studies have underscored their significance in slope stability analysis.
Wei Cao, Wei Cao, Wenjing Li, Haiyang Yi, Yuanyuan Liu   +4 more
doaj   +1 more source

Periodic-coefficient damping estimates, and stability of large-amplitude roll waves in inclined thin film flow [PDF]

, 2015
A technical obstruction preventing the conclusion of nonlinear stability of large-Froude number roll waves of the St. Venant equations for inclined thin film flow is the "slope condition" of Johnson-Noble-Zumbrun, used to obtain pointwise ...
Rodrigues, Luis Miguel, Zumbrun, Kevin
core   +5 more sources

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

slope stability analysis [PDF]

, 2014
  +5 more sources