Results 61 to 70 of about 23,822,382 (306)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
On Slip Surface and Slope Stability Analysis
Soils and Foundations, 1975 ABSTRACT The method of variational calculus is applied to obtain the shape of slip surface and the corresponding normal stress distribution. For a horizontal slope of uniform soil, a logarithmic spiral surface of angle φ is found to be the most critical surface. This contradicts the report made earlier by Spencer (1969).
CHEN, W.F., SNITBHAN, N.
openaire +2 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Torque sum method for slope stability analysis
Yantu gongcheng xuebaoA new method for analyzing slope stability, the torque sum method (TSM), is proposed. The TSM is on the basis of the vector sum method (VSM), considering the displacement mode of the landslide mass as a rigid body and supplementing the displacement ...
CHEN Wensheng, LIU Cheng, XU Bin, YIN Pingbao
doaj +1 more source
Effect of intermediate principal stress on the stability of slopes [PDF]
Archives of Civil EngineeringThe intermediate principal stress (σ2 ) effect is a mechanical property inherent in many rock and soil materials. However, the effect of σ2 is often ignored in slope stability analyses, and its impact on slope stability is seldom investigated.
Zongyuan Ma, Lei Liu
doaj +1 more source
Research on Upper Bound Limit Stability Analysis of Multi-Step High Steep Slope
Advances in Civil Engineering, 2023 In order to explore the stability of multi-step high steep slope, this paper considers layer distribution of soil and builds a slope failure mechanism which meets requirements of velocity separation based on plastic mechanics principles, then derives the
Zhen Wang
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Stability Analysis of Soil Slopes Using Limilt Analysis
Shuitu baochi yanjiu, 2005 The limit equilibrium method is commonly used for slope stability analysis.Limit equilibrium method however is not rigorous because neither static nor kinematical admissibility conditions are satisfied.Limit analysis takes advantage of the lower-and ...
ZHAO Zhi-xing~1 +2 more
doaj
, 2017 Slope stability monitoring and evaluating play vital role in the risk management of open cast mines. Generally, Issue of slope failure occurs at open cast mines due to undisciplined mining, impacts of weather conditions.
Ritika Rathee, Ajay Kumar
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source