Results 111 to 120 of about 435,657 (302)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Risk assessment model of expansive soil slope stability based on Fuzzy-AHP method and its engineering application

Geomatics, Natural Hazards & Risk, 2018
To systematically evaluate the risk grade of stability of expansive soil slope during construction, the recognition model is established by using the fuzzy recognition theory and the analytic hierarchy process (AHP).
Jian Zhang, Peng He, Jie Xiao, Fei Xu
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Monitoring of ground condition into road decrepit slopes by seismic and electric prospecting [PDF]

, 2010
A large number of shotcrete slopes that were constructed in Japan during the 1970’s are now more than 30 years old, and there has been a significant degree of deterioration.
Kusumi Harushige, Nakamura Makoto, Yamamoto Tatsuru, Yamamoto Tsuyoshi, 中村 真, 山本 剛, 山本 龍, 楠見 晴重   +7 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Safety Assessment of Tunnel Portals for Site Selection Based on Spatial Information Geoprocessing

Infrastructures, 2019
The evaluation of portal locations for mountain tunnels is among the most crucial considerations during route selection and structural layout planning. The development of spatial information technology has provided a more objective approach for assessing
Iau-Teh Wang
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Study on the initiation mechanism and motion characteristics of the Daguangbao landslide and the slope stability evaluation method

Frontiers in Built Environment
Landslide triggered by earthquake has always been the hotspot due to its large scale, unique genesis, and complex kinematic processes. In this paper, the Daguangbao landslide in the 2008 Wenchuan Ms8.0 earthquake is selected as the research object.
Dejie Yu, Dejie Yu, Lei Liu, Lei Liu, Yue Ding, Fan Yang, Xiangyu Zhang   +6 more
doaj   +1 more source

Numerical analysis for slopes stability evaluation. Comparative study

Journal of Physics: Conference Series
Abstract Currently, slope stability is assessed either theoretically, using various calculations methods, or practically, by directly monitoring ground deformations. The modelling of geotechnical structures, particularly slopes, through computational programs has advanced significantly over the past decades. These programmes are based on
R M Chirilă, O E Colț, V Mușat
openaire   +1 more source