Results 51 to 60 of about 435,657 (302)

Implementing Health‐Related Quality of Life Assessment in Pediatric Oncology: A Feasibility Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background There is growing interest in embedding health‐related quality of life (HRQoL) assessment and patient‐reported outcome measures (PROMs) within clinical cancer care. This study evaluated the feasibility, acceptability, and usability of implementing an electronic PROM (ePROM) platform to measure HRQoL in children with cancer ...
Mikaela Doig, Sophie Jessop, Jordan R. Hansford, Hien Le, Matthew O'Connor, Peter Gorayski, Andrew Cunningham, Amanda Hutchinson, Victoria Bedford, Eva Bezak, Nayana Parange, Kelly Skelton, Timothy Price, Michala Short   +13 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

A New Method for Slope Risk Stability Assessment: Combined Weighting and Improved Cloud Matter‐Element Model

Engineering Reports
In order to accurately evaluate the grade of slope stability and reduce the risk of geological disasters, a comprehensive evaluation method of slope stability based on game theory and finite interval cloud matter element model is proposed. Firstly, based
Wan‐Rui Hu, Heng Liu, Xing‐Tao Zhou, Bo Wei, Ceng Shang, Peng Guan   +5 more
doaj   +1 more source

Effect of operating temperature on direct recycling aluminium chips (AA6061) in hot press forging process [PDF]

, 2013
A method of solid-state recycling aluminum alloy using hot press forging process was studied as well as the possibility of the recycled chip to be used as secondary resources.
Ahmad, Mohd Hafizi, Ayop, Osman, Faizol, Zulbirri, Jusoh, Muzammil, Majid, Huda A., Mat Saman, Norhafezaidi, Rahim, Mohamad Kamal A., Yusoff, Zubaida, Zubir, Farid   +8 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Seismic Slope Stability Evaluation Considering Rock Mass Disturbance Varying in the Slope

KSCE Journal of Civil Engineering, 2019
Seismic effect is one of the most commonly considered factors in rock slope safety design. This study adopts the finite element lower bound limit analysis method to study the seismic stability of disturbed rock slopes considering inhomogeneity caused by rock mass disturbance.
Li, An-Jui, Qian, Zhiguang, Jiang, Jing-Cai, Lyamin, Andrei   +3 more
openaire   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Open-pit mine slopes stability analysis based on analytic hierarchy process-fuzzy comprehensive evaluation model

Zhongguo dizhi zaihai yu fangzhi xuebao
The bench slope within an open-pit coal mine plays an important supporting role for coal resource production and transportation. The stability evaluation of the slope is of great significance in guiding continuous mining operations within the mine.
Zhiguo LI, Tao XU, Yongjie LIU, Lichun ZHAO, Yongchao XU, Tianhong YANG, Xiaobin ZHENG   +6 more
doaj   +1 more source