Results 91 to 100 of about 117,118 (314)

Costamere remodeling with muscle loading and unloading in healthy young men [PDF]

, 2013
Costameres are mechano-sensory sites of focal adhesion in the sarcolemma that provide a structural anchor for myofibrils. Their turnover is regulated by integrin-associated focal adhesion kinase (FAK).
Erskine, Robert M., Seynnes, Olivier R., Simunic, B, Narici, MV, Flück M., Pisot, R, Flück, M., Rittweger J., Rittweger, Joern, Flueck, M, Narici M. V., Narici, Marco, Narici, Marco V., Flück, Martin, Seynnes O. R., Erskine, Robert, Li R., Rittweger, Jörn, Rittweger, J, Pisot, Rado, Seynnes, Olivier R, Seynnes, OR, Pišot R., Seynnes, Olivier, Li, Ruowei, Erskine, Robert M, Narici, Marco V, Erskine, RM, Šimunič B., Narici, Marco Vincenzo, Simunic, Bostjan, Erskine R. M., Li, R   +32 more
core   +1 more source

Timing is everything: The effect of early‐life seizures on developing neuronal circuits subserving spatial memory

Epilepsia Open, EarlyView.
Abstract Spatial memory, the aspect of memory involving encoding and retrieval of information regarding one's environment and spatial orientation, is a complex biological function incorporating multiple neuronal networks. Hippocampus‐dependent spatial memory is not innate and emerges during development in both humans and rodents.
Gregory L. Holmes
wiley   +1 more source

Epilepsy syndromes classification

Epilepsia Open, EarlyView.
Abstract Epilepsy syndromes are distinct electroclinical entities which have been recently defined by the International League Against Epilepsy Nosology and Definitions Task Force. Each syndrome is associated with “a characteristic cluster of clinical and EEG features, often supported by specific etiologic findings”.
Elaine C. Wirrell, Nicola Specchio, Rima Nabbout, Phillip L. Pearl, Kate Riney   +4 more
wiley   +1 more source

Longevity of cardiac and skeletal muscle proteins is dependent on tissue and subcellular compartmentation patterns

Cell Reports
Summary: Myocytes are exceptionally long-lived cells that must maintain proteome integrity over decades while adjusting for changes in functional output and metabolic demand.
Jack Gugel, Jordan Currie, Lorena Alamillo, Jason Flint, Keun-Young Kim, Marc Debliqui, Mark H. Ellisman, Maggie P.Y. Lam, Edward Lau, Rafael Arrojo e Drigo, Leslie Leinwand   +10 more
doaj   +1 more source

Distinct signal transductions in fast- and slow- twitch muscles upon denervation

Physiological Reports, 2018
Denervation induces skeletal muscle atrophy, which primarily impairs oxidative slow twitch fibers. The underlying mechanism of this phenomenon, however, remains to be addressed. We hypothesize that denervation-induced fiber-specific atrophy may result from the distinct activities of different signaling pathways that are involved in protein synthesis ...
Gao, Hongbo, Li, Yi‐Fan
openaire   +2 more sources

Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes

Epilepsia Open, EarlyView.
Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola, Marica Rubino, Antonella Riva, Pasquale Striano   +3 more
wiley   +1 more source

Influence of Different Obstetric Factors on Early Postpartum Pelvic Floor Function in Primiparas After Vaginal Delivery

International Journal of Women's Health, 2023
Xiaolei Chi,1,2,* Shushu Yu,1,2,* Kun Zhu,3 Yiyao Chen,1,2 Yi Chu,1,2 Xinliang Chen1,2 1Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai,
Chi X, Yu S, Zhu K, Chen Y, Chu Y, Chen X   +5 more
doaj  

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Development temperature has persistent effects on muscle growth responses in gilthead sea bream [PDF]

, 2012
Initially we characterised growth responses to altered nutritional input at the transcriptional and tissue levels in the fast skeletal muscle of juvenile gilthead sea bream.
Darias, Maria Jose, Maria Darias (110381), Vieira-Johnston, Vera Lucia Almeida, Ian A Johnston (110394), Garcia de la serrana Daniel, Estévez Alicia, Andree, Karl B, Alicia Estévez, Johnston, I.A., Karl B Andree, Vieira Vera L. A., Maria Darias, Johnston Ian A, Alicia Estévez (110385), Enric Gisbert (110389), Darias, Maria, Daniel Garcia de la serrana (110372), Garcia de la Serrana Castillo, Daniel, Andree Karl B., Darias Maria, Gisbert, E., Garcia de la Serrana, D., Estévez, Alicia, Vera L A Vieira, Vieira, V.L.A, Daniel Garcia de la serrana, Vera L. A. Vieira (110374), Garcia de la Serrana, Daniel, Andree, K.B., Vieira, Vera L.A., Andree, Karl, Johnston, Ian A., Estevez, A., Karl B. Andree (110377), Gisbert Enric, Gisbert, Enric, Enric Gisbert, Johnston, Ian Alistair, Ian A Johnston   +38 more
core   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source