Results 61 to 70 of about 117,118 (314)

miR-493-3p promotes porcine muscle satellite cells differentiation and the formation of slow muscle fibers through MKK7/JNK axis

Agriculture Communications
MicroRNAs (miRNAs) are key regulators of porcine myogenesis. In this study, we elucidated the regulatory role of miR-493-3p in skeletal muscle development.
Lingling Wu, Zhaolu Wang, Xiaoting Wu, Yidi Zhang, Gongshe Yang, Jianjun Jin, Xin'e Shi   +6 more
doaj   +1 more source

SESN2 prevents the slow-to-fast myofiber shift in denervated atrophy via AMPK/PGC-1α pathway

Cellular & Molecular Biology Letters, 2022
Background Sestrin2 (SESN2), a stress-inducible protein, has been reported to protect against denervated muscle atrophy through unfolded protein response and mitophagy, while its role in myofiber type transition remains unknown.
Xiaofan Yang, Pingping Xue, Zhenyu Liu, Wenqing Li, Chuyan Li, Zhenbing Chen   +5 more
doaj   +1 more source

Dynamic properties of denervated fast and slow twitch muscle of the cat

The Journal of Physiology, 1974
1. Isometric and isotonic contractions were recorded from cat flexor digitorum longus (FDL) and soleus muscles denervated for 28–35 days and compared with the responses of contralateral control muscles.2. Isometric twitch time to peak was longer in the denervated muscles than in the controls.
C J, Kean, D M, Lewis, J D, McGarrick
openaire   +3 more sources

Light‐Assisted 3D Printing Techniques and Photocrosslinking Strategies: Recent Advances in Musculoskeletal Tissue Engineering

Advanced Engineering Materials, EarlyView.
In this review, the current state of light‐assisted 3D printing as it pertains to engineering musculoskeletal tissues including bone, cartilage, skeletal muscle, tendon, and ligaments is summarized. Common printing techniques, photoreactive materials, and study design choices are compiled and reviewed.
Meagan Morgan, Bin Zhang, Roger Narayan
wiley   +1 more source

Phosphoproteomic analysis identifies differentially expressed phosphorylation sites that affect muscle fiber type in pigs

Frontiers in Nutrition, 2022
Skeletal muscle of livestock is composed of both fast- and slow-twitch muscle fibers, which are key factors in their meat quality. However, the role of protein phosphorylation in muscle fiber type is not completely understood. Here, a fast-twitch (biceps
Yu He, Xiaofan Tan, Hongqiang Li, Zhiwei Yan, Jing Chen, Ruixue Zhao, David M. Irwin, Wangjun Wu, Shuyi Zhang, Bojiang Li   +9 more
doaj   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

Function of mTOR complex 1 and 2 in skeletal muscle [PDF]

, 2009
Growth of an organ during development and during adaptation in the adult can be controlled by alterations either in the number or the size of cells. The two mechanisms are fundamentally different and require distinct regulation.
Bentzinger, Conrad Florian
core   +1 more source

Need for speed: Human fast-twitch mitochondria favor power over efficiency

Molecular Metabolism
Objective: Human skeletal muscle consists of a mixture of slow- and fast-twitch fibers with distinct capacities for contraction mechanics, fermentation, and oxidative phosphorylation.
Sebastian Edman, Mikael Flockhart, Filip J. Larsen, William Apró   +3 more
doaj   +1 more source

Additive‐Manufactured, Multifunctional Bioreactor Technology for Dynamic Culture of 3D Bioprinted Tissue Models

Advanced Materials Technologies, EarlyView.
We introduce an additively manufactured bioreactor with a perfusion flow system and integrated temperature and pH sensors for skeletal muscle tissue biofabrication. The bioreactor's performance was evaluated by assessing the viability, spreading of the myoblast cells in a printed scaffold, and contraction of the isolated murine musculi interossei ...
Lys Sprenger, Johann Schorzmann, Hsuan‐Heng Lu, Muhammad Osama, Julian Bauer, Michael Haug, Oliver Friedrich, Aldo R. Boccaccini, Frank Döpper, Sahar Salehi   +9 more
wiley   +1 more source

Exhausting treadmill running causes dephosphorylation of sMLC2 and reduced level of myofilament MLCK2 in slow twitch rat soleus muscle [PDF]

, 2015
Myosin light chain 2 (MLC2) is a small protein in the myosin complex, regulating muscle contractile function by modulating Ca2+ sensitivity of myofilaments.
Lunde, Per Kristian, Sjaastad, Ivar, Lunde, Ida G, Aronsen, Jan Magnus, Hortemo, Kristin Halvorsen, Sejersted, Ole M, Lunde, Ida Gjervold   +6 more
core   +1 more source