Results 91 to 100 of about 828,066 (290)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Cogent Business & ManagementGrowing environmental concerns have led to much research on the ethical shift in how people shop. Consumer attitudes toward sustainable products have emerged, though consumers prefer them, and actual purchases remain minimal, showing the existence of the
Pappu Sindhuja +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Textiles, connection and meaning [PDF]
, 2010 Why do some items of clothing remain safely housed in our wardrobes whilst others are quickly relegated to opportunity shops? This paper will investigate the practical, emotional and nostalgic connections people make with their possessions.
Lynas, E
core
Nonequilibrium dynamics in a two-channel Kondo system due to a quantum quench
, 2010 Recent experiments by Potok et al. have demonstrated a remarkable tunability between a single-channel Fermi liquid fixed point and a two-channel non-Fermi liquid fixed point.
A. C. Hewson +3 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Digital Approach to Slow Fashion
Fashion HighlightThis paper discusses the design of “I finded,” a mobile app aimed at mapping and promoting second-hand clothing stores within Porto’s historic centre. Developed as part of a master’s thesis at the University of Porto in 2023, the app addresses the rising interest in second-hand clothing and the limited awareness of such shops in Porto.
Susana Barreto, Ana Carolina Fidelis
openaire +1 more source
HAADF-STEM block-scanning strategy for local measurement of strain at the nanoscale
, 2020 Lattice strain measurement of nanoscale semiconductor devices is crucial for the semiconductor industry as strain substantially improves the electrical performance of transistors.
Bender, Hugo +5 more
core +2 more sources
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source