Results 101 to 110 of about 127,937 (288)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Bali - pusat fashion nusantara: meruangkan warisan budaya sebagai slow fashion

, 2021
Pakaian atau Fashion merupakan sebuah bagian dari 3 kebutuhan primer manusia yang merupakan sebuah syarat untuk bertahan hidup. Pada awalnya, pakaian merupakan sebuah objek yang diproduksi untuk memenuhi sebuah kebutuhan manusia; diproduksi secara ...
Suanto, Felix
core  

Digital Approach to Slow Fashion

Fashion Highlight
This paper discusses the design of “I finded,” a mobile app aimed at mapping and promoting second-hand clothing stores within Porto’s historic centre. Developed as part of a master’s thesis at the University of Porto in 2023, the app addresses the rising interest in second-hand clothing and the limited awareness of such shops in Porto.
Susana Barreto, Ana Carolina Fidelis
openaire   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Slow and fast fashion

, 2012
This text describes the benefits of diversifying strategies for sustainability in fashion, and demonstrateshow design can be applied beyond the product level.
Tham, Mathilda,
core  

SLOW FASHION AND ELEMENTS OF SUSTAINABILITY AS A CRITIQUE OF FAST FASHION SYSTEM THROUGH OWN FASHION COLLECTION EXAMPLE

, 2021
Slow fashion i elementi održivosti kao kritika fast fashion sistema na primjeru vlastite modne kolekcije, diplomski je rad u kojem se skreće pozornost na problematičnosti modne industrije do kojih je došlo u zadnjih nekoliko godina pojavom fast fashion ...
Vrbica, Nika
core  

Slow fashion vs fast fashion en Instagram [PDF]

, 2022
El sector de la moda es uno de los más contaminantes a nivel mundial. Durante los últimos años el consumo desmedido ha aumentado con ayuda de redes sociales como Instagram, la cual ha servido como plataforma para que estas empresas crezcan a pesar de que
Abdala Galvis, Salma Shireen Yaber, Camacho Uribe, María Gabriela   +1 more
core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source