Results 121 to 130 of about 2,816,735 (333)

Creativity in firms case-study : slow Artist [PDF]

, 2015
The world in which we live in is in the process of constant changes and shifts. These changes affect all societies and firms as we are in a global world where limits and boundaries are being steadily eradicated.
Martín Pitarch, Laura
core  

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Tapol bulletin no, 161, March/April 2001 [PDF]

, 2001
Contents: Deadly conflict in Central Kalimantan -- Human rights defenders slain in cold blood -- All out war in Aceh as US oil company halts operations -- Suharto-style trials back in fashion -- The birth of a new organisation -- PRD takes Suharto to ...

core  

Pre - Inflationary Clues from String Theory ?

, 2014
"Brane supersymmetry breaking" occurs in String Theory when the only available combinations of D-branes and orientifolds are not mutually BPS and yet do not introduce tree-level tachyon instabilities.
A. Gruppuso, A. Gruppuso ., A. Kamenev, A. Sagnotti, A. Sagnotti, A. Sagnotti, A. Sen, A.A. Andrianov, A.Y. Kamenshchik, B. Zwiebach, C. Condeescu, C.V. Johnson, D.H. Lyth, D.S. Gorbunov, D.Z. Freedman, E. Bergshoeff, E. Dudas, E. Dudas, E. Kiritsis, E.A. Bergshoeff, E.A. Bergshoeff, F.G. Pedro, G. Aldazabal, G.F. Giudice, G.F. Giudice, I.P.C. Heard, J. Ellis, J. Martin, J. Polchinski, J. Wess, J.M. Maldacena, K. Becker, M. Cicoli, M. Shifman, M.B. Green, N. Kitazawa, P. Fré, P. Fré, P.K. Townsend, Planck collaboration, Planck collaboration, Planck collaboration, Planck collaboration, R. Barbieri, R. Bousso, R. Emparan, R. Kallosh, R. Kallosh, R.K. Jain, S. Ferrara, S. Ferrara, S. Ferrara, S. Weinberg, S.V. Ketov, V. Mukhanov, V.F. Mukhanov, V.F. Mukhanov, WMAP collaboration, WMAP collaboration, Y. Golfand, Y. Golfand, Z.-G. Liu   +61 more
core   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Thermally Activated Magnetization and Resistance Decay during Near Ambient Temperature Aging of Co Nanoflakes in a Confining Semi-metallic Environment

, 2011
We report the observation of magnetic and resistive aging in a self assembled nanoparticle system produced in a multilayer Co/Sb sandwich. The aging decays are characterized by an initial slow decay followed by a more rapid decay in both the ...
Aaron Barnes, Benjamin Grove, Christopher Heidt, Gregory. G. Kenning, Henkel Malte, James Martin, Michael Madden, Morrish A. H., Neel L., Struik L. C. E., Weast Robert C.   +10 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Animation, Fashion and Sustainability [PDF]

, 2019
This paper presents an experiment, within a PhD project, to create a two-dimensional (2D) fashion design tool using animation techniques. The tool appropriates Adobe After Effects software (incurring low costs) supporting innovation early in the design ...
McKelvey, Kathryn
core