Results 51 to 60 of about 890,712 (298)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
INTERAKSI SOSIAL SISWA SLOW LEARNER [PDF]
, 2018 AbstrakPenelitian ini bertujuan untuk mengetahui bentuk-bentuk interaksi sosial siswa slow learner di kelas III SD Muhammadiyah 2 Magelang. Bentuk-bentuk interaksi sosial meliputi bentuk kerjasama, akomodasi, persaingan, kontravensi, dan menghadapi ...
Wati, Roh Dinia
core
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Slow learner aid mobile application / Nurul Huda Abd Rahman [PDF]
, 2015 Several points have been identified where they lead to the success of this project. The problem statement of this project are the slow learner have a difficulty in maintaining social interaction and social skills, they may have a poor self-confidence and
Abd Rahman, Nurul Huda
core
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
, 1962 Problem: It is the purpose of this study to more adequately define the slow learner and his problems, and to identify and evaluate methods of dealing with the slow learner in the classroom and to teach the slow learner to think more effectively ...
Brentner, Howard J.
core +1 more source
Mastery of Basic Mathematics Facts in Slow Learner Children [PDF]
, 2021 As one of the mathematics objects, the basic facts of mathematics are the primary material that students must master. The facts of addition and subtraction should have been taught in the first level and mastered by the end of the second level.
Subanti, Sri +5 more
core +4 more sources