Results 61 to 70 of about 890,712 (298)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Invited Guest Editorial: Just Saying: For H/heaven’s Sake… Here’s Hoping --- “All Hell Could Break Loose!”

Journal of Applied Hermeneutics, 2016
If you have been reading, to date, in the Journal of Applied Hermeneutics, Dr. John Williamson’s PhD thesis-come-novel serialized, then you have read, more or less, four texts:   • Guest Editorial: Preface to “A Strange and Earnest Client” Part One of ...
Jim Paul
doaj   +1 more source

PARENTAL INVOLVEMENT PADA ORANG TUA DENGAN ANAK SLOW LEARNER DI BANDUNG

, 2021
: PARENTAL INVOLVEMENT ON PARENTS OF SLOW LEARNER CHILDREN IN BANDUNG Slow learner is one of students’ characteristics that need special treatment in inclusive schools.
Hamdan, Stephani Raihana, Lutfiatin, Marissa Putri, Stephani Raihana Hamdan, Marissa Putri Lutfiatin   +3 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

PERILAKU SLOW LEARNER DALAM PEMBELAJARAN BERBASIS SPADA (STUDI KASUS PADA MAHASISWA PENDIDIKAN BIOLOGI UMB)

, 2023
This study aims to know the behavior of Slow Learner students in SPADA learning in the laboratory operastional management engineering course.  The research was classified as qualitative research with an case study methode.
Akbar, Fauzan, Ulfa, Andi Yurni, Andi Yurni Ulfa, Fauzan Akbar   +3 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Langkah Kolaboratif Guru dalam Manajemen dan Intervensi Pembelajaran Model Pull Out bagi Siswa Slow Learner

Ideguru
Pembelajaran bagi siswa slow-learner membutuhkan perlakuan yang lebih khusus dibandingkan dengan siswa pada umumnya. Langkah kolaboratif perlu dilakukan bersama Guru dan orangtua guna mendapatkan data dan proses yang komprehensif bagi kemajuan siswa ...
Fajar Fithroni, Wiwit Ika Setiyati, Abdurrahman Abdurrahman, Wahid Aditiono, Raphael Krismanto Priyoatmojo   +4 more
doaj   +1 more source