Results 71 to 80 of about 377,857 (257)

Journal des apprentissages, réflexivité et difficulté scolaire

open access: yesRepères, 2008
Having pupils write their learning diaries in elementary school is in line with a current trend which tends to emphasize reflexiveness in the early school years. Does this practice benefit pupils with important learning difficulties ?
Jacques Crinon
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Experimenting with twilight learnings and twilight writings for community engagement

open access: yesGateways
This contribution explores community engagement through the collaborative practice ‘Twilight Learnings – Seasonal experiments in the Tiny House on Wheels (THoW)’.
Silvia Mugnaini   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Heuristique de la lenteur

open access: yesCarnets de Géographes, 2015
Slowness – seen as aiôn or lived time – is a key-tool for a geographical fieldwork: analysis of three research stays in Indonesia (2006-2008, 2009, 2013) prove as much.
Jean-Baptiste Bing
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Poetry as method – trying to see the world differently

open access: yesResearch for All, 2020
Research with communities, even co-produced research with a commitment to social justice, can be limited by its expression in conventional disciplinary language and format.
doaj   +2 more sources

Desideri, fallimenti, resistenze: figure femminili nella narrativa di J.M. Coetzee

open access: yesBetween, 2013
Desire is a constant presence in J.M. Coetzee's fiction. Coetzee's narrators unremittingly wonder about desire: the more their position is "authorial", the more these fictional characters' reflections on this issue are consciously bound to writing and ...
Giulia Zanfabro
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

SLOW HEALING: ENVIRONMENTAL AND SOCIAL JUSTICE IN UNBOWED: A MEMOIR

open access: yesAnkara Üniversitesi Dil ve Tarih-Coğrafya Fakültesi Dergisi
In her autobiography Unbowed: A Memoir (2006), Wangari Maathai, a political activist and Nobel Peace Prize winner, depicts environmental and political struggle against the legacies of colonialism.
Hediye Özkan
doaj   +1 more source

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