Results 241 to 250 of about 118,693 (302)

RAB4A acts as a negative feedback regulator of extracellular vesicle secretion during TGF‐β signaling

The FEBS Journal, EarlyView.
TGF‐β signaling regulates extracellular vesicle (EV) release in cancer cells by modulating the expression and activity of genes associated with EV biogenesis. The TGF‐β‐induced upregulation of RAB4A expression facilitates fast endosomal recycling, a process that limits the fusion of multivesicular bodies with the plasma membrane and EV secretion. Hence,
Dorival Mendes Rodrigues‐Junior, Maria Anastasia Doumani, Hao Fu, Jelle van den Bor, Olof Idevall‐Hagren, Aristidis Moustakas   +5 more
wiley   +1 more source

Molecular Mechanisms of Cardiac Fibrosis: A Pathologist's Perspective. [PDF]

Curr Issues Mol Biol
Marzullo A, Salzillo C.
europepmc   +1 more source

Genomic Analysis of Inbreeding Depression on Productive Traits in Rubia Galega Beef Cattle Breed

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT In autochthonous livestock breeds with small populations, such as the Rubia Galega from Galicia (Spain), mating between relatives is common and can lead to inbreeding depression. Genomic inbreeding coefficients were estimated for 4984 animals using ~63,000 SNPs to assess inbreeding depression in four key traits: age at first calving (AFC) with
N. Mejuto‐Vázquez, C. Hervás‐Rivero, R. Rodríguez‐Bermúdez, D. López‐Carbonell, M. Hermida, P. Martínez, L. Varona   +6 more
wiley   +1 more source

Lathyrol Exerts Anti-Pulmonary Fibrosis Effects by Activating PPARγ to Inhibit the TGF-β/Smad Pathway. [PDF]

Int J Mol Sci
Zeng Q, Liao ML, Luo YY, Li S, You G, Huang CM, Liu MH, Liu W, Tang SY.   +8 more
europepmc   +1 more source

Epithelial‐Mesenchymal Transition, Immune Response, and Extracellular Matrix Remodelling in Oral Cancer

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Aim This retrospective study investigates the interplay between epithelial‐mesenchymal transition (EMT) and immune response within the tumor microenvironment (TME) of oral squamous cell carcinoma (OSCC). Methodology Immunohistochemistry was conducted on OSCC specimens to evaluate the expression of podoplanin (PDP), E‐cadherin (CDH1), vimentin (
Nicole Lonni, Camilla Kammer Pereira, Amanda Maciel Costa, Aline Hsiao Bona, Andressa Fernanda Paza Miguel, Elis Ângela Batistella, Daniella Serafin Couto Vieira, Elena Riet Correa Rivero   +7 more
wiley   +1 more source

Losartan attenuates depression-like behavior in epileptic rats by regulating the TGF-β/Smad signaling. [PDF]

IBRO Neurosci Rep
Cao P, Shen S, Fang Z, Tan J, Wang J, Pan N.   +5 more
europepmc   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

Interplay between TGF-β signaling and long non-coding RNAs in digestive system cancers: mechanisms and biological implications. [PDF]

Hum Cell
Li P, Huang D, Gu X.
europepmc   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source

Phellodendron amurense Rupr. Polysaccharides protects against diabetic nephropathy via alteration of PI3K/GSK-3β/Nrf2/TGF-β/Smad signaling pathway and gut microbiota. [PDF]

Nat Prod Bioprospect
Mei M, Sun H, Zhang K, Zhang F, Sun S, Zhang Y.   +5 more
europepmc   +1 more source