Results 251 to 260 of about 118,693 (302)

Exosomes Regulate Liver Diseases Through the TGF-β1/Smads Signaling Pathway and the Intervention of Traditional Chinese Medicine: A Narrative Review. [PDF]

J Inflamm Res
Huang G, Zhou Z.
europepmc   +1 more source

Effect of the antifungal drug ciclopirox on the inhibition of HMGA2-mediated oncogenic capacity in ACHN renal cell carcinoma. [PDF]

Front Pharmacol
Liu X, Su J, Song L, Fu Q, Li X, Li J, Liu Y, Liao J.   +7 more
europepmc   +1 more source

Personalized signaling pathway analysis of gastrointestinal tumors for patient stratification and drug target evaluation using clinically derived core biopsies. [PDF]

NPJ Precis Oncol
Stahl A, Büringer K, Missios P, Hoffmann T, Mattern S, Singer S, Schäfer-Ruoff F, Malek NP, Schenke-Layland K, Bitzer M, Templin MF.   +10 more
europepmc   +1 more source

The long noncoding RNA VIM-AS1 and nucleoporin Nup358/RanBP2 regulate SMAD nuclear accumulation during TGF-β signaling. [PDF]

Nucleic Acids Res
Rodrigues-Junior DM, Ali MM, Itoh Y, Ferreira MS, Heldin J, Fu H, Hoelz A, Heldin CH, Moustakas A.   +8 more
europepmc   +1 more source

TGF-β1/SMAD signaling downregulates KLF4 expression via direct transcriptional suppression and FAT10-mediated proteasomal degradation in hepatocellular carcinoma. [PDF]

Cell Biosci
Chen Z, Zhao S, Chen D, Lou Y, Lu H, Yao Q, Lu J, Sun H.   +7 more
europepmc   +1 more source

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TGF-β signaling by Smad proteins

Cytokine & Growth Factor Reviews, 2000
Members of the transforming growth factor-beta (TGF-beta) family bind to type II and type I serine/threonine kinase receptors, which initiate intracellular signals through activation of Smad proteins. Receptor-regulated Smads (R-Smads) are anchored to the cell membrane by interaction with membrane-bound proteins, including Smad anchor for receptor ...
K, Miyazono, P, ten Dijke, C H, Heldin
openaire   +4 more sources

Identification of novel Smad binding proteins

Biochemical and Biophysical Research Communications, 2003
The TGFbetas, a family of secreted polypeptide growth factors, are critical regulators of mammalian orofacial development. The importance of the TGFbetas in development of the orofacial region in mice is underscored by the resulting orofacial clefts in mice with targeted deletion of either TGFbeta2 or TGFbeta3 and most recently, a conditional knockout ...
Dennis R, Warner, Emily A, Roberts, Robert M, Greene, M Michele, Pisano   +3 more
openaire   +2 more sources

Recombinant Expression and Purification of Smad Proteins

Protein Expression and Purification, 2000
Smads transduce intracellular signals initiated by members of the transforming growth factor beta (TGF beta) family, including activins, TGF betas, and bone morphogenetic proteins. Recently, various models concerning the mechanism of Smad action have been proposed; however, these models are basically qualitative.
M, Funaba, L S, Mathews
openaire   +2 more sources