Results 261 to 270 of about 118,693 (302)

Regulation of Smad signaling by protein kinase C

The FASEB Journal, 2001
ABSTRACT Cross talk between transforming growth factor β (TGF‐β) serine/threonine kinase receptor signaling and tyrosine kinase receptor signaling modulates cell responsiveness to polypeptide growth factors regulating cell proliferation, differentiation, and apoptosis.
I, Yakymovych, P, Ten Dijke, C H, Heldin, S, Souchelnytskyi   +3 more
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Molecular Evolution of Smad Proteins

2007
To date, Smad family members have been found only in eumetazoan animals. To understand the evolutionary relationship between family members we conducted a phylogenetic analysis. To simplify the analysis but retain its explanatory power, we focused on Smad proteins from organisms in three distinct phyla: human, fly, and nematode.
Stuart J. Newfeld, Robert G. Wisotzkey
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SMAD proteins and mammalian anatomy

Nature, 1998
Members of the transforming growth factor-β (TGF-β) family, which signal through SMAD proteins, are involved in many developmental processes. Inactivation of the genes encoding two of the SMAD proteins, Smads 2 and 4, shows that both are required to lay down some of the primary layers of the animal body.
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Cellular response to hypoxia involves signaling via Smad proteins

Blood, 2003
The transforming growth factor-β (TGF-β) family of cytokines regulates vascular development and inflammatory responses. We have recently shown that exposure of human umbilical vein endothelial cells (HUVECs) to hypoxia (1% O2) increases gene expression and bioactivation of TGF-β2 and induces its downstream effectors, Smad proteins (Smads), to associate
Hong, Zhang, Hasan O, Akman, Eric L P, Smith, Jin, Zhao, Joanne E, Murphy-Ullrich, Olcay A, Batuman   +5 more
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Smad interacting protein 1 influences transforming growth factor-β1/Smad signaling in extracellular matrix protein production and hypertrophic scar formation

Journal of Molecular Histology, 2019
The transforming growth factor (TGF)-β/Smad signal transduction pathway is closely associated with hypertrophic scar (HS) formation. Smad interacting protein 1 (SIP1) is a cytoplasmic protein that efficiently regulates Smad2-/3-dependent signaling within the TGF-β1 pathway.
Xiaobing, Fang, Xiaolong, Hu, Zhao, Zheng, Ke, Tao, Hongtao, Wang, Hao, Guan, Jihong, Shi, Peng, Ji, Weixia, Cai, Xiaozhi, Bai, Xiongxiang, Zhu, Juntao, Han, Jiaqi, Liu, Dahai, Hu   +13 more
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Signal Transduction of the TGF-  Superfamily by Smad Proteins

Journal of Biochemistry, 1999
Members of the TGF-beta superfamily regulate the growth and differentiation of various types of cells. Smads are recently identified proteins that mediate intracellular signaling of the TGF-beta superfamily. Smads are grouped into three classes depending on their structure and functions.
M, Kawabata, K, Miyazono
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Distribution of Smad mRNA and proteins in the rat brain

Journal of Chemical Neuroanatomy, 2018
Smad proteins are known to transduce the action of TGF-β superfamily proteins including TGF-βs, activins, and bone morphogenetic proteins (BMPs). In this study, we examined the expression of Smad1, -2, -3, -4, -5, and -8 mRNA in the rat brain by means of RT-PCR and in situ hybridization (ISH). In addition, we examined the nuclear accumulation of Smad1,
Takayuki, Nakajima, Ryusuke, Hata, Yuji, Kunieda, Tomohiro, Kondo   +3 more
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Overexpression of Smad proteins, especially Smad7, in oral epithelial dysplasias

Clinical Oral Investigations, 2012
Transforming growth factor β, via membrane-bound receptors and downstream Smad2-4, 7, can modulate tumorigenesis. Smad2 and Smad3 heterodimerize with Smad4, and the complex migrates to the nucleus to regulate the expression of target genes. Smad7 is a key negative regulator of this signaling pathway.
Yuk-Kwan, Chen, Anderson Hsien-Cheng, Huang, Pei-Hsun, Cheng, Shang-Hsun, Yang, Li-Min, Lin   +4 more
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Regulation of Smad signalling by protein associations and signalling crosstalk

Trends in Cell Biology, 1999
Smads are intracellular signalling mediators for the family of transforming growth factor beta (TGF-beta)-related growth and differentiation factors, which signal through transmembrane serine/threonine kinases. Following receptor-induced activation, heteromeric Smad complexes translocate into the nucleus, where they act as transcription factors. Recent
Y, Zhang, R, Derynck
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Integration of Signaling Pathways Via Smad Proteins

2007
TGF-β ligands are involved in most aspects of embryonic development and post-natal homeostasis and numerous examples of crosstalk with other signaling pathways have been described. The Smad proteins are the most extensively characterized signal transducers downstream of the TGF-β superfamily of secreted growth factors. In most cases, Smad proteins have
Etienne Labbé, Liliana Attisano
openaire   +1 more source