Results 131 to 140 of about 1,611,169 (342)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Coded Aperture Nuclear Scintigraphy: A Novel Small Animal Imaging Technique

, 2002
We introduce and demonstrate the utility of coded aperture (CA) nuclear scintigraphy for imaging small animals. CA imaging uses multiple pinholes in a carefully designed mask pattern, mounted on a conventional gamma camera.
John Idoine, Dawid Schellingerhout, Umar Mahmood, Richard C. Lanza, Ralph Weissleder, Roberto Accorsi   +5 more
core   +1 more source

Effects of long-term high-dose prednisolone in Beagle dogs on structural and functional responses of the HPA Axis

BMC Veterinary Research
Background Long-term glucocorticoid administration can suppress the hypothalamic-pituitary-adrenal (HPA) axis, increasing the risk of adrenal insufficiency upon withdrawal, with an unpredictable recovery timeline.
Felicitas S. Boretti, Livia Harburger, Barbara Riond, Elisabeth Neubert, Regina Hofmann-Lehmann, Stefan Unterer, Matthias Dennler, Nadja S. Sieber-Ruckstuhl   +7 more
doaj   +1 more source

Editorial: Small animal imaging: Technological and methodological advances to improve the translational power. [PDF]

Front Med (Lausanne), 2022
Bernsen MR, McDougald W, Mezzanotte L, Moran CM, Tavares A, van der Weerd L.   +5 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Assessment of cell cycle arrest biomarkers and neutrophil gelatinase‐associated lipocalin to distinguish acute kidney injury from other diseases in dogs

Journal of Veterinary Internal Medicine
Background Cell cycle arrest biomarkers (tissue inhibitor of metalloproteinase‐2 [uTIMP‐2] and insulin‐like growth factor binding protein 7 [uIGFBP7]), and neutrophil gelatinase‐associated lipocalin (NGAL) variables are valuable biomarkers for early ...
Ann Biscop, Donatienne Castelain, Emmelie Stock, Kristel Demeyere, Evelyne Meyer, Nausikaa Devriendt, Elisabeth Dorn, Nikita De Laet, Dominique Paepe   +8 more
doaj   +1 more source

Short-wave infrared fluorescence imaging of near-infrared dyes with robust end-tail emission using a small-animal imaging device. [PDF]

PNAS Nexus, 2023
Arena F, La Cava F, Faletto D, Roberto M, Crivellin F, Stummo F, Adamo A, Boccalon M, Napolitano R, Blasi F, Koch M, Taruttis A, Reitano E.   +12 more
europepmc   +1 more source

Small Animal Imaging Resource Programs

Definitions, 2020

semanticscholar   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Small Animal Molecular Imaging Toolbox (SAMIT)

, 2014
The aim of this toolbox is to facilitate the construction of new tracer specific templates and the subsequent voxel-based analysis of small animal PET and SPECT brain images.
Univ Med Ctr Groningen, University of Groningen, Vállez García, David; id_orcid, Dierckx, Rudi, Molecular Neuroscience and Ageing Research (MOLAR), Doorduin, Janine, Univ Groningen RUG, University of Groningen, UMCG, Dept Pathol & Med Biol, Vállez García, David, Schwarz, A, Koole, M., Casteels, Cindy, Katholieke Univ Leuven, KU Leuven, Mol Small Anim Imaging Ctr, MoSAIC, Doorduin, Janine; id_orcid   +11 more
core   +1 more source