Results 111 to 120 of about 1,611,169 (342)

Small-Animal Optical Imaging [PDF]

Journal of Biomedical Optics, 2008
Vasilis Ntziachristos, Joseph P. Culver, Bradley W. Rice, null Special Section Guest Editors   +3 more
openaire   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Differential Diagnosis in Small Animal Medicine

, 2015
A vital pocket-sized reference tool for busy practitioners and students, saving hours of searching through multiple sources. Differential Diagnosis in Small Animal Medicine, Second Edition brings together comprehensive differential diagnosis lists ...
Murphy, Kate, Gough, Alex
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Imaging Microglial/Macrophage Activation in Spinal Cords of Experimental Autoimmune Encephalomyelitis Rats by Positron Emission Tomography Using the Mitochondrial 18kDa Translocator Protein Radioligand [18F]DPA-714 [PDF]

, 2012
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS. Activated microglia/macrophages play a key role in the immunopathogenesis of MS and its corresponding animal models, experimental autoimmune encephalomyelitis (EAE).
Thézé, Benoit, Dollé, Frédéric, Brulon, Vincent, Fontyn, Yoann, Abourbeh, Galith, Dubois, Albertine, Tavitian, Bertrand, Boisgard, Raphael, Maroy, Renaud   +8 more
core   +1 more source

Crossed fused renal ectopia in a Persian cat

Journal of Feline Medicine and Surgery Open Reports, 2017
Case summary This report describes a rare case of crossed fused renal ectopia (CFRE) in a cat. A mature intact male Persian cat presented with bloody nasal discharge and ascites. Diagnostic studies revealed an ectopic left kidney fused with an orthotopic
Sang-Hyuk Seo, Hyun-A Lee, Sang-Il Suh, Ran Choi, In-Chul Park, Changbaig Hyun   +5 more
doaj   +1 more source

Monitoring of Tumor Promotion and Progression in a Mouse Model of Inflammation-Induced Colon Cancer with Magnetic Resonance Colonography

Neoplasia: An International Journal for Oncology Research, 2009
Early detection of precancerous tissue has significantly improved survival of most cancers including colorectal cancer (CRC). Animal models designed to study the early stages of cancer are valuable for identifying molecular events and response indicators
Matthew R. Young, Lilia V. Ileva, Marcelino Bernardo, Lisa A. Riffle, Yava L. Jones, Young S. Kim, Nancy H. Colburn, Peter L. Choyke   +7 more
doaj   +1 more source

Metastatic Cholangiocarcinoma in a Bearded Dragon (Pogona vitticeps)

Acta Veterinaria, 2020
A 6.5-year-old female bearded dragon (Pogona vitticeps) was presented with a swollen right pelvic limb. A tissue core biopsy from the swollen area was performed and a presumptive histopathological diagnosis of adenocarcinoma was made.
Dominik Komenda, Tamara Dolenšek, Tanja Švara, Marjan Kastelic, Pavel Proks, Ivana Nývltová, Pavel Kvapil   +6 more
doaj   +1 more source

Photo-multiplier Tube Based Hybrid MRI and Frequency Domain Fluorescence Tomography System for Small Animal Imaging

Physics in Medicine and Biology, 2011
Fluorescence tomography (FT) is a promising molecular imaging technique that can spatially resolve both fluorophore concentration and lifetime parameters.
Yuting Lin, M. Ghijsen, Hao Gao, N. Liu, Orhan Nalcioglu, Orhan Nalcioglu, G. Gulsen   +6 more
semanticscholar   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source