Results 101 to 110 of about 1,611,169 (342)

Features of the NIH atlas small animal pet scanner and its use with a coaxial small animal volume CT scanner [PDF]

, 2002
Proceeding of: 2002 IEEE International Symposium On Biomedical Imaging, Washington, D.C., USA, July 7-10, 2002ATLAS (Advanced Technology Laboratory Animal Scanner), a small animal PET scanner designed to image animals the size of rats and mice, is about
Pascau González-Garzón, Javier, Green, Michael V., Seidel, Jürgen, Vaquero, Juan José, Johnson, Calvin A., Pascau González Garzón, Javier, Desco Menéndez, Manuel, Desco, Manuel, Vaquero López, Juan José, Pascau, Javier   +9 more
core   +1 more source

Outcome in Critically Ill Dogs and Dogs With Acute Kidney Injury Based on Neutrophil Gelatinase‐Associated Lipocalin and Tissue Inhibitor of Metalloproteinase‐2

Journal of Veterinary Internal Medicine
Background Neutrophil gelatinase‐associated lipocalin (NGAL) and tissue inhibitor of metalloproteinase‐2 (TIMP‐2) have potential as early biomarkers for acute kidney injury (AKI) in dogs. Objectives Assess whether NGAL and TIMP‐2 at admission (T0) and 24 
Elisabeth Dorn, Ann Biscop, Nausikaa Devriendt, Donatienne Castelain, Kristel Demeyere, Emmelie Stock, Evelyne Meyer, Dominique Paepe   +7 more
doaj   +1 more source

Diverse Responses to Vascular Disrupting Agent Combretastatin A4 Phosphate: A Comparative Study in Rats with Hepatic and Subcutaneous Tumor Allografts Using MRI Biomarkers, Microangiography, and Histopathology

Translational Oncology, 2013
OBJECTIVE: Differently located tumors of the same origin may exhibit diverse responses to the same therapeutics. To test this hypothesis, we compared the responses of rodent hepatic and subcutaneous engrafts of rhabdomyosarcoma-1 (R1) to a vascular ...
Junjie Li, Feng Chen, Yuanbo Feng, Marlein Miranda Cona, Jie Yu, Alfons Verbruggen, Jian Zhang, Raymond Oyen, Yicheng Ni   +8 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Small Animal Imaging using a Clinical Positron Emission Tomography/Computed Tomography and Super-Resolution

Molecular Imaging, 2012
Considering the high cost of dedicated small-animal positron emission tomography/computed tomography (PET/CT), an acceptable alternative in many situations might be clinical PET/CT. However, spatial resolution and image quality are of concern.
F. Difilippo, Sagar S. Patel, K. Asosingh, S. Erzurum   +3 more
semanticscholar   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Accurate molecular imaging of small animals taking into account animal models, handling, anaesthesia, quality control and imaging system performance [PDF]

, 2015
Small-animal imaging has become an important technique for the development of new radiotracers, drugs and therapies. Many laboratories have now a combination of different small-animal imaging systems, which are being used by biologists, pharmacists ...
Bankstahl, Jens P., Jens P. Bankstahl, Nicola Belcari, Krämer, Stefanie, Belcari, Nicola, Krämer, Stefanie D., Stefanie D. Krämer, Stefaan Vandenberghe, Bankstahl, Jens, Vandenberghe, Stefaan, Visser, Eric, Christian Vanhove, Eric Visser, Vanhove, Christian   +13 more
core   +1 more source

Effects of isoflurane, sevoflurane, propofol and alfaxalone on brain metabolism in dogs assessed by proton magnetic resonance spectroscopy (1H MRS)

BMC Veterinary Research, 2018
Background The purpose of this study was to determine the effects of isoflurane, sevoflurane, propofol and alfaxalone on the canine brain metabolite bioprofile, measured with single voxel short echo time proton magnetic resonance spectroscopy at 3 Tesla.
Franz Josef Söbbeler, Inés Carrera, Kirby Pasloske, Millagahamada Gedara Ranasinghe, Patrick Kircher, Sabine Beate Rita Kästner   +5 more
doaj   +1 more source