Results 81 to 90 of about 1,611,169 (342)

Towards a novel small animal proton irradiation platform: the SIRMIO project [PDF]

, 2019
Background: Precision small animal radiotherapy research is a young emerging field aiming to provide new experimental insights into tumour and tissue models in different microenvironments, to unravel the complex mechanisms of radiation damage in target ...
Würl, Matthias, Schreiber, Jörg, Thirolf, Peter G., Bortfeldt, Jonathan, Kurichiyanil, Neeraj, Wieser, Hans-Peter, Kalunga, Ronaldo, Assmann, Walter, Safari, Mohammad, Parodi, Katia, Meyer, Sebastian, Nitta, Munetaka, Lämmer, Paulina, Lovatti, Giulio, Dedes, George, Schnürle, Katrin, Kundel, Sonja, Pinto, Marco, Belka, Claus, Clevert, Dirk-André, Lascaud, Julie, Lauber, Kirsten   +21 more
core   +1 more source

Optimization and performance study of a proton CT system for pre-clinical small animal imaging [PDF]

, 2020
Proton computed tomography (pCT) promises to reduce or even eliminate range uncertainties inherent in the conversion of Hounsfield units into relative stopping power (RSP) for proton therapy treatment planning.
Lämmer, Paulina, Würl, Matthias, Englbrecht, Franz S., Schnürle, Katrin, Bortfeldt, Jonathan, Pinto, Marco, Meyer, Sebastian, Parodi, Katia, Englbrecht, Franz S   +8 more
core   +1 more source

In vivo and contrast-enhanced ex vivo micro-computed tomography for anatomical imaging of Octodon degus

Heliyon
Octodon degus, a rat-sized rodent species endemic to central Chile, can spontaneously develop human-like pathological conditions in captivity. Its relatively long gestation period of ∼90 days provides an opportunity for studies of embryonic development ...
Daniel Amaya, Sergi Llambrich, Kasia Błażejczyk, Greetje Vande Velde, Peter Mombaerts   +4 more
doaj   +1 more source

New-generation small animal positron emission tomography system for molecular imaging

Journal of Medical Imaging, 2017
. The next generation of discoveries in molecular imaging requires positron emission tomography (PET) systems with high spatial resolution and high sensitivity to visualize and quantify low concentrations of molecular probes.
S. Abbaszadeh, C. Levin
semanticscholar   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

A spontaneously metastatic model of bladder cancer: imaging characterization

Journal of Translational Medicine, 2019
Background Spontaneously metastatic xenograft models of cancer are infrequent and the few that exist are resource intensive. In xenografts, caliper measurements can be used to determine primary tumor burden and response to therapy but in metastatic ...
James L. Tatum, Joseph D. Kalen, Paula M. Jacobs, Lilia V. Ileva, Lisa A. Riffle, Melinda G. Hollingshead, James H. Doroshow   +6 more
doaj   +1 more source

Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Since SARS-CoV-2 emerged in China, it has spread rapidly around the world. Effective vaccines and therapeutics for SARS-CoV-2−induced disease (coronavirus disease 2019;COVID-19) are urgently needed.
M. Imai, K. Iwatsuki-Horimoto, M. Hatta, S. Loeber, P. Halfmann, N. Nakajima, Tokiko Watanabe, M. Ujie, Kenta Takahashi, Mutsumi Ito, Shinya Yamada, Shufang Fan, S. Chiba, M. Kuroda, Lizheng Guan, Kosuke Takada, T. Armbrust, A. Balogh, Y. Furusawa, M. Okuda, H. Ueki, A. Yasuhara, Yuko Sakai-Tagawa, Tiago J. S. Lopes, Maki Kiso, S. Yamayoshi, N. Kinoshita, N. Ohmagari, S. Hattori, M. Takeda, H. Mitsuya, F. Krammer, Tadaki Suzuki, Y. Kawaoka   +33 more
semanticscholar   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source