Results 231 to 240 of about 20,833,215 (297)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Development of Autoranging Functionality to Enhance the Sensitivity of Helical Capacitance Level Sensors via Neural Networks. [PDF]

Sensors (Basel)
Hanni JR, Venkata SK.
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Evaluation of the subtype-specific epigenetic prognostic association of HELLS in non-small cell lung cancer: integrated clinical and molecular insights. [PDF]

Transl Cancer Res
Lee Y, Lee J, Park JH, Kim J, Lee JH.
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Bayesian Convolutional Neural Networks for Uncertainty-Aware Classification of Infrasound Events. [PDF]

Sensors (Basel)
Yin H, Zhang K, Lu Y, Chang Y, Wu Y, Yang F, Li X, Xu J, Pang X.   +8 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Split-spectrum amplitude decorrelation optoretinography for functional imaging of mouse photoreceptors. [PDF]

Biomed Opt Express
Matteson A, Helms M, Fraley L, Hurt A, Andrews A, White E, Yang P, Everett L, Chen S.   +8 more
europepmc   +1 more source

Brain Clearance of Contrast Agent in Intravenous DCE-MRI Is Measurable and Cannot Be Explained by Clearance Across the BBB Alone. [PDF]

Magn Reson Med
Kozár M, Mosneag IE, Al-Bachari S, Chernyavsky I, Parker GJM, Boutin H, Parkes LM, Schiessl I, Dickie BR.   +8 more
europepmc   +1 more source

Robust Detection of Small Moving Objects Against Real-World Complex Dynamic Natural Environments: Drosophila-Inspired Visual Neural Pathway Modeling. [PDF]

Biomimetics (Basel)
Zhang S, Li K, Luo Z.
europepmc   +1 more source