Results 121 to 130 of about 543,226 (367)

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

Bod1, a novel kinetochore protein required for chromosome biorientation [PDF]

, 2007
We have combined the proteomic analysis of Xenopus laevis in vitro–assembled chromosomes with RNA interference and live cell imaging in HeLa cells to identify novel factors required for proper chromosome segregation. The first of these is Bod1, a protein
Andersen, Jens S., Blow, J. Julian, Hunter, Christopher J., Khoudoli, Guennadi A., McAinsh, Andrew D., McClelland, Sarah E., Porter, Iain M., Swedlow, Jason R.   +7 more
core   +3 more sources

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Optimal Electroporation Condition for Small Interfering RNA Transfection into MDA-MB-468 Cell Line

Iranian Journal of Medical Sciences, 2012
Background: Electroporation is a valuable tool for small interfering RNA (siRNA) delivery into cells because it efficiently transforms a wide variety of cell types.
Rita Arabsolghar, Mozhgan Rasti
doaj  

Small Interfering RNAs Targeting VP4, VP3, 2B, or 3A Coding Regions of Enterovirus A71 Inhibit Viral Replication In Vitro

Biomedicines
Background: Enterovirus A71 (EV-A71) is considered as the primary causative agent of hand, foot, and mouth disease (HFMD) in young children, leading to severe neurological complications and contributing to substantial mortalities in recent HFMD outbreaks
Yun Ji Ga, Yun Young Go, Jung-Yong Yeh
doaj   +1 more source

Nanodiamond as a vector for siRNA delivery to Ewing sarcoma cells

, 2011
We investigated the ability of diamond nanoparticles (nanodiamonds, NDs) to deliver small interfering RNA (siRNA) in Ewing sarcoma cells, in the perspective of in vivo anti-cancer nucleic acid drug delivery.
Barnard, Bertrand, Bolte, Boudou, Caliceti, Chang, Chen, Choosakoonkriang, Chow, Chung, Creusat, Dantelle, de Martimprey, Diaz-Lopez, El Badawy, Elhamess, Faklaris, Fattal, Guan, Horcajada, Huang, Huang, Kaiser, Kurosaki, Liang, Liu, Maksimenko, Maksimenko, Mohan, Nakada, Pouton, Qi, Ramon, Rondin, Schrand, Schrand, Simovic, Tanaka, Tang, Toub, Vaijayanthimala, Vial, Xia, Xu, Yuan, Yuan, Zhang, Zoubek   +47 more
core   +3 more sources

RNA Viruses: RNA Roles in Pathogenesis, Coreplication and Viral Load. [PDF]

, 2015
The review intends to present and recapitulate the current knowledge on the roles and importance of regulatory RNAs, such as microRNAs and small interfering RNAs, RNA binding proteins and enzymes processing RNAs or activated by RNAs, in cells infected by
Massimo Mallardo,, Poltronieri, Palmiro, Sun, Binlian   +2 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Functional Nanostructures for Effective Delivery of Small Interfering RNA Therapeutics

Theranostics, 2014
Small interfering RNA (siRNA) has proved to be a powerful tool for target-specific gene silencing via RNA interference (RNAi). Its ability to control targeted gene expression gives new hope to gene therapy as a treatment for cancers and genetic diseases.
Cheol Am Hong, Y. Nam
semanticscholar   +1 more source

Delivery of small-interfering RNA (siRNA) to the brain [PDF]

Expert Opinion on Therapeutic Patents, 2009
Two fundamental difficulties in the delivery of drugs to treat central nervous system (CNS) diseases are the systemic delivery of therapeutics across the bloodbrain-barrier (BBB), and the targeting of drugs to specific tissues or cells within the brain.
openaire   +3 more sources