Results 131 to 140 of about 545,365 (346)

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Farnesylated heat shock protein 40 is a component of membrane-bound RISC in Arabidopsis [PDF]

, 2018
ARGONAUTE1 (AGO1) binds directly to small regulatory RNA and is a key effector protein of post-transcriptional gene silencing mediated by microRNA (miRNA) and small interfering RNA (siRNA) in Arabidopsis. The formation of an RNA-induced silencing complex
Barghetti, Andrea, Brodersen, Peter, Floris, Maina, Linding, Rune, Sjögren, Lars, Völlmy, Franziska   +5 more
core   +1 more source

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

FEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna, Richard Buchal, Martin Leníček, Amit Shachak, Jan Pláteník   +4 more
wiley   +1 more source

Role of RNA Interference (RNAi) in the Moss Physcomitrella patens [PDF]

, 2013
RNA interference (RNAi) is a mechanism that regulates genes by either transcriptional (TGS) or posttranscriptional gene silencing (PTGS), required for genome maintenance and proper development of an organism.
Arif, Muhammad Asif, Frank, Wolfgang, Khraiwesh, Basel   +2 more
core   +3 more sources

Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies

FEBS Open Bio, EarlyView.
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa, Ilva Liekniņa, Svetlana Koteloviča, Ramona Petrovska, Gediminas Žvinys, Agne Petrosiute, Asta Zubrienė, Matīss Toms Laugalis, Vendija Skeltona, Juris Jansons, Madara Kreishmane, Edita Čapkauskaitė, Daumantas Matulis, Kaspars Tārs   +13 more
wiley   +1 more source

A Simple and Innovative Method for Cell Membrane Passing the Small Interfering RNA (siRNA) in Eukaryotic Cells; Toxoplasma Gondii as an Experience

مجله دانشکده پزشکی اصفهان, 2017
Background: Eukaryotic cells have membrane organelles. Due to the high prevalence of toxoplasmosis and lack of effective drugs especially on dormant cystic stages, we aimed adding small interfering RNA (siRNA) in culture medium on the proliferation ...
Abbas Ali Eskandarian, Mogtaba Azimi-Resketi   +1 more
doaj  

Small Interfering RNA Targeting Nerve Growth Factor Alleviates Allergic Airway Hyperresponsiveness

Molecular Therapy: Nucleic Acids, 2014
Airway hyperresponsiveness is the hallmark of allergic asthma and caused by multiple factors. Nerve growth factor (NGF), a neurotrophin, is originally known for regulation of neural circuit development and function.
Yi-Lien Chen, Hsin-Ying Huang, Chen-Chen Lee, Bor-Luen Chiang   +3 more
doaj   +1 more source

An Open-Label, Multicenter, Phase I, Dose Escalation Study with Phase II Expansion Cohort to Determine the Safety, Pharmacokinetics, and Preliminary Antitumor Activity of Intravenous TKM-080301 in Subjects with Advanced Hepatocellular Carcinoma. [PDF]

, 2019
Lessons learnedTKM-080301 showed a favorable toxicity profile at the studied dose.TKM-080301 targeting PLK1 through small interfering RNA mechanism did not demonstrate improved overall survival in patients with advanced hepatocellular carcinoma compared ...
Abou-Alfa, Ghassan K, Brown, Joanne, Chao, Tsu-Yi, Choi, Hye Jin, El Dika, Imane, Freilich, Bradley, Kelley, Robin K, Knox, Jennifer, Lim, Ho Yeong, Lin, Chia-Chi, Modiano, Manuel, Ryoo, Baek-Yeol, Yau, Thomas, Yong, Wei Peng, Yoon, Jung-Hwan   +14 more
core   +1 more source

Improved silencing properties using small internally segmented interfering RNAs [PDF]

, 2007
RNA interference is mediated by small interfering RNAs (siRNAs) that upon incorporation into the RNA-induced silencing complex (RISC) can target complementary mRNA for degradation. Standard siRNA design usually feature a 19–27 base pair contiguous double-
Bramsen, Jesper B., Damgaard, Christian K., Kjems, Jørgen, Laursen, Maria B., Lena, Suzy W., Ravindra Babu, B., Wengel, Jesper   +6 more
core   +2 more sources

SGlycosylation Gene Signatures as Prognostic Biomarkers in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioblastoma (GBM) is an aggressive brain tumor characterized by significant heterogeneity. This study investigates the role of glycosylation‐related genes in GBM subtyping, prognosis, and response to therapy. Methods We analyzed mRNA expression data and clinical information from The Cancer Genome Atlas (TCGA) and Gene Expression ...
Tong Zhao, Hongliang Ge, Chenchao Lin, Xiyue Wu, Jianwu Chen   +4 more
wiley   +1 more source