Results 141 to 150 of about 352,358 (326)

RNA Interference as a New Tool in Therapeutics

Food Technology and Biotechnology, 2009
The basic principle of RNA interference, a possible new therapeutic tool, involves destruction of messenger RNA upon interaction with homologous double-stranded RNA present in the cell cytoplasm.
Karmela Barišić, Mirela Matokanović
doaj  

Engineering Lipid–Polymer Nanoparticles for siRNA Delivery to Cancer Cells

Pharmaceuticals
Background: RNA interference (RNAi) is a powerful tool that can target many proteins without the expensive and time-consuming drug development studies. However, due to the challenges in delivering RNA molecules, the potential impact of RNAi approaches is
Arthur Manda, Abdulelah Alhazza, Hasan Uludağ, Hamidreza Montazeri Aliabadi   +3 more
doaj   +1 more source

Combination of small interfering RNAs mediates greater suppression on hepatitis B virus cccDNA in HepG2.2.15 cells

, 2008
Xiaomin Xin, Guiqiu Li, Ying-Yu Jin, Min Zhuang, Di Li   +4 more
openalex   +2 more sources

Emerging 2D Materials and Their Hybrid Nanostructures for Label‐Free Optical Biosensing: Recent Progress and Outlook

Advanced Functional Materials, EarlyView.
This review highlights recent advances in label‐free optical biosensors based on 2D materials and rationally designed mixed‐dimensional nanohybrids, emphasizing their synergistic effects and novel functionalities. It also discusses multifunctional sensing platforms and the integration of machine learning for intelligent data analysis.
Xinyi Li, Yonghao Fu, Yuehe Lin, Dan Du
wiley   +1 more source

RNA interference therapy in cardiology: will new targets improve therapeutic goals?

Drugs in Context
The discovery of RNA interference in 1998 opened avenues for the manipulation of gene expression, leading to the development of small interfering RNA (siRNA) drugs.
Renata TJ Fazoli, Luciano F Drager, Roberto Kalil-Filho, Giuliano Generoso   +3 more
doaj   +1 more source

Precision delivery of RAS-inhibiting siRNA to KRAS driven cancer via peptide-based nanoparticles [PDF]

, 2019
Over 95% of pancreatic adenocarcinomas (PDACs), as well as a large fraction of other tumor types, such as colorectal adenocarcinoma, are driven by KRAS activation. However, no direct RAS inhibitors exist for cancer therapy.
Bi, Ye, Brooks, Candace, DeNardo, David G, Fields, Ryan C, Fleming, Timothy, Gillanders, William E, Goedegebuure, S Peter, Hawkins, William G, Krasnick, Bradley A, Pan, Hua, Sankpal, Narendra, Strand, Matthew S, Wetzel, Christopher, Wickline, Samuel A, Zhang, Xiuli   +14 more
core   +1 more source

Approaches for Studying MicroRNA and Small Interfering RNA Methylation In Vitro and In Vivo

, 2007
Zhiyong Yang, Giedrius Vilkaitis, Bin Yu, Saulius Klimašauskas, Xuemei Chen   +4 more
openalex   +2 more sources

Targets of Small Interfering RNA Restriction during Human Immunodeficiency Virus Type 1 Replication [PDF]

, 2008
Yong Gao, Michael A. Lobritz, Justin C. Roth, Measho Abreha, Kenneth N. Nelson, Immaculate Nankya, Dawn M. Moore‐Dudley, Awet Abraha, Stanton L. Gerson, Eric J. Arts   +9 more
openalex   +1 more source

Oral Dosed Organo‐Silica Nanoparticles Restore Glucose Homeostasis and β‐Cell Function in Diabetes Rats

Advanced Functional Materials, EarlyView.
An oral nanoplatform, MOP@T@D, which can maintain glucose homeostasis and restore islet β cells in diabetic rats is developed. It achieves efficient intestinal absorption and liver‐targeted delivery. The nanoparticle disintegrates only in response to hyperglycemia to release insulin on demand and provides antioxidant protection through selenoprotein ...
Chenxiao Chu, Mingli Wei, Che Bian, Xiaoshuang Bi, Yaxin Deng, Peifu Xiao, Jiansong Zhao, Yuying Wang, Haibing He, Jingxin Gou, Tian Yin, Xing Tang, Li Yang, Hongbo Zhang, Yu Zhang   +14 more
wiley   +1 more source

small interfering RNA molecule

Citation: 'small interfering RNA molecule' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.11225 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms ...
openaire   +1 more source