Advanced Healthcare Materials, EarlyView.The PVA‐GA hydrogel is formed through hydrogen bonding between PVA hydroxyl groups and GA galloyl units, enabling sustainable GA release and its extended biological activity. The hydrogel scavenges ROS to reduce oxidative stress, preventing mitochondrial damage from excessive ROS, mitigating hADSC senescence, and preserving VEGF secretion, offering a ...
Yiduo Zhou +11 more
wiley +1 more source
Evidence that TRPC1 (transient receptor potential canonical 1) forms a Ca2+-permeable channel linked to the regulation of cell volume in liver cells obtained using small interfering RNA targeted against TRPC1 [PDF]
, 2003 Jinglong Chen, Greg J. Barritt
openalex +1 more source
Engineering Assembloids to Mimic Graft‐Host Skeletal Muscle Interaction
Advanced Healthcare Materials, EarlyView.This study develops a graft‐host skeletal muscle assembloid model combining neuromuscular organoids with tissue‐engineered constructs. Pre‐seeding decellularized muscles with myogenic cells enhances cell migration and axon invasion from the organoid. The model exhibits regenerative capacity following acute damage, advancing the understanding of human ...
Lucia Rossi +13 more
wiley +1 more source
Small interfering RNA (siRNA) inhibits the expression of the Her2/neu gene, upregulates HLA class I and induces apoptosis of Her2/neu positive tumor cell lines [PDF]
, 2003 Aniruddha Choudhury +6 more
openalex +1 more source
DeepSilencer: A Novel Deep Learning Model for Predicting siRNA Knockdown Efficiency [PDF]
arXivBackground: Small interfering RNA (siRNA) is a promising therapeutic agent due to its ability to silence disease-related genes via RNA interference. While traditional machine learning and early deep learning methods have made progress in predicting siRNA efficacy, there remains significant room for improvement.
arxiv
Transvascular delivery of small interfering RNA to the central nervous system
Nature, 2007 Priti Kumar +8 more
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.The scaffold‐free Anchored Cell Sheet Engineering platform is used to create three‐dimensional (3D) in vitro models of skeletal muscle tissue that replicate key features of Duchenne and Myotonic dystrophies. These personalized tissue models, validated by histological, immunostaining, and proteomics analyses, accurately mimic disease phenotypes and ...
Alireza Shahin‐Shamsabadi +1 more
wiley +1 more source
RNA Interference as a New Tool in Therapeutics
Food Technology and Biotechnology, 2009 The basic principle of RNA interference, a possible new therapeutic tool, involves destruction of messenger RNA upon interaction with homologous double-stranded RNA present in the cell cytoplasm.
Karmela Barišić, Mirela Matokanović
doaj
RNA interference therapy in cardiology: will new targets improve therapeutic goals?
Drugs in ContextThe discovery of RNA interference in 1998 opened avenues for the manipulation of gene expression, leading to the development of small interfering RNA (siRNA) drugs.
Renata TJ Fazoli +3 more
doaj +1 more source
Argonaute Protein in the Early Divergent Eukaryote Trypanosoma brucei: Control of Small Interfering RNA Accumulation and Retroposon Transcript Abundance [PDF]
, 2003 Huafang Shi +3 more
openalex +1 more source