The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang+2 more
wiley +1 more source
Diabetes-induced mechanophysiological changes in the small intestine and colon
The disorders of gastrointestinal (GI) tract including intestine and colon are common in the patients with diabetes mellitus (DM). DM induced intestinal and colonic structural and biomechanical remodeling in animals and humans.
Mirabella Zhao, D. Liao, Jingbo Zhao
semanticscholar +1 more source
Radiation from ingested wireless devices in bio-medical telemetry bands [PDF]
The performance of wireless devices, using electrically small antennae, in the human intestine is investigated using the finite difference time domain method in recommended biomedical device telemetry bands.
Chirwa, L.C., Cumming, D.R.S., Roy, S.
core +1 more source
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu+17 more
wiley +1 more source
Novel aspects of Wnt signaling in intestinal development and cancer [PDF]
The gastrointestinal tract is a highly specialized organ system responsible for the processing of ingested food, including the uptake of nutrients and the removal of waste products.
Bakker, E.R.M. (Elvira)
core +8 more sources
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan+2 more
wiley +1 more source
The use of the Ussing chamber system to investigate iron absorption by the duodenum, jejunum and ileum in the mouse : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Physiology at Massey University, Palmerston North, New Zealand [PDF]
Iron deficiency anaemia is found in approximately 30% of the worlds population and is particularly prevalent in developing countries. The majority of these deficiencies are due to insufficient absorption of iron from the diet.
Edmunds, Shelley Jane
core
Electromagnetic radiation from ingested sources in the human intestine between 150 MHz and 1.2 GHz [PDF]
The conventional method of diagnosing disorders of the human gastro-intestinal (GI) tract is by sensors embedded in cannulae that are inserted through the anus, mouth, or nose.
Chirwa, L.C.+3 more
core +1 more source
Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász+6 more
wiley +1 more source
Development of Small and Large Intestine
Epithelial components of the organs of the digestive system are derived from endoderm whereas connective tissue and muscle components are derived from mesoderm. At the 3-4th of development, as a result of cephalocaudal and lateral foldings of the embryo,
Mukaddes EŞREFOĞLU, Aslı ÇETİN
doaj +1 more source