Results 81 to 90 of about 8,043,335 (383)

An analysis of cosecretion and coexpression of gut hormones from male rat proximal and distal small intestine.

open access: yesEndocrinology, 2015
Gut endocrine cells are generally thought to have distinct localization and secretory products. Recent studies suggested that the cells are highly related and have potential to express more than one hormone. We studied the coexpression and cosecretion of
B. Svendsen   +7 more
semanticscholar   +1 more source

An investigation into the relationship between small intestinal fluid secretion and systemic arterial blood pressure in the anesthetized rat [PDF]

open access: yes, 2015
In the absence of an ability to absorb fluid by cellular uptake mechanisms, fluid movement in vivo from the perfused rat intestine is absorptive when the diastolic blood pressure is normal or very low but is secretory when blood pressure falls below ...
Lucas, Michael, Morrison, James
core   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Small Intestine in Psoriasis [PDF]

open access: yesBMJ, 1967
Twenty-three female and 19 male patients were studied. Their ages ranged from 15 to 72 years. The total length of history of psoriasis ranged from 3 weeks to 50 years, and the duration of the most recent episode from 1 week to 20 years. All patients had been admitted to hospital for treatment and were studied consecutively, apart from a few who ...
Sam Shuster   +2 more
openaire   +3 more sources

Transplantation of the small intestine: the pathologist's perspective. [PDF]

open access: yes, 1990
Small-bowel transplantation is now ready for clinical trials. The surgical techniques and methods for immunosuppression and monitoring bowel status have been developed in animal models over the past 30 years.
Banner, B   +4 more
core  

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

open access: yesMolecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti   +10 more
wiley   +1 more source

КОМПЛЕКСНАЯ КЛИНИКО-ФУНКЦИОНАЛЬНАЯ ОЦЕНКА ТОНКОЙ КИШКИ ПРИ МЕТАБОЛИЧЕСКОМ СИНДРОМЕ

open access: yesАрхивъ внутренней медицины, 2015
Aim: complex investigation of the small intestine functional condition in metabolic syndrome.Materials and methods.120 patients with metabolic syndrome were examined. We used clinical data and complex examination of the small intestine function.
Я. М. Вахрушев   +1 more
doaj   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

Live Intravital Intestine with Blood Flow Visualization in Neonatal Mice Using Two-photon Laser Scanning Microscopy

open access: yesBio-Protocol, 2021
This protocol describes a novel technique to investigate the microcirculation dynamics underlying the pathology in the small intestine of neonatal mice using two-photon laser-scanning microscopy (TPLSM).
Yuhki Koike   +12 more
doaj   +1 more source

Free fatty acid receptor GPR120 is highly expressed in enteroendocrine K cells of the upper small intestine and has a critical role in GIP secretion after fat ingestion.

open access: yesEndocrinology, 2015
Gastric inhibitory polypeptide (GIP) is an incretin secreted from enteroendocrine K cells in response to meal ingestion. Recently free fatty acid receptor G protein-coupled receptor (GPR) 120 was identified as a lipid sensor involved in glucagon-like ...
Kanako Iwasaki   +14 more
semanticscholar   +1 more source

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