Results 221 to 230 of about 777,845 (296)

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

Molecular detection and typing of pathogenic Leptospira species from livestock and small mammals in Uganda. [PDF]

Epidemiol Infect
Alinaitwe L, Wainaina M, Dürr S, Kankya C, Kivali V, Bugeza J, Aturinda CJ, Lubega A, Mayer-Scholl A, Hoona JJ, Bahn P, Hammerl JA, Roesel K, Cook EAJ, Richter MH.   +14 more
europepmc   +1 more source

DCAF13 Safeguards Hematopoietic Stem Cells via RRS1‐Regulated Ribosome Biogenesis

Advanced Science, EarlyView.
This study establishes DCAF13 as an essential regulator for hematopoietic stem cell (HSC) function. Its deletion in mice causes lethal pancytopenia and HSC depletion. Mechanistically, DCAF13 interacts with RRS1 and mediates its non‐degradative K27‐linked ubiquitination, thereby stabilizing RRS1 to maintain ribosome biogenesis and protein translation ...
Mengke Li, Yuxin Wu, Shuai Zhou, Peipei Tang, Jiaming Wei, Ling Liu, Zhenyi Wang, Deyang Shi, Shengnan Yuan, Qingyu Zhang, Shihui Wang, Qing Zhang, Huan Zhao, Rui Zhang, Yingying Wang, Shiwei Yang, Xiangli Chen, Xiaojing Shi, Guangzhi Liu, Yuwei Zhang, Jinming Li, Xu Dong Zhang, Rick F Thorne, Dongping Wei, Zumin Zhu, Song Chen   +25 more
wiley   +1 more source

Low-cost physiology and behavioral monitor for intravital imaging in small mammals. [PDF]

Neurophotonics
Li Y, Cardenas-Rivera A, Liu C, Lu Z, Anton J, Alfadhel M, Yaseen MA.   +6 more
europepmc   +1 more source

Palmitoylation‐Mediated Ubiquitination of SRPK1 Regulates Ferroptosis in High‐Fat‐Induced Erectile Dysfunction

Advanced Science, EarlyView.
Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan, Ke‐Fan Li, Yi‐Ming Yuan, Man‐Cheng Xia, Fang‐Zhou Zhao, Hong‐Gang Ying, Zhuo Zhou, Peng‐Chao Gao, Guo‐Qing Xie, Xue‐Song Li, Hui Jiang, Rui‐Li Guan   +11 more
wiley   +1 more source

Extreme Body Condition Index Values in Small Mammals. [PDF]

Life (Basel)
Balčiauskas L, Balčiauskienė L.
europepmc   +1 more source

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, EarlyView.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

The on-Site Monitoring and Specimen-Making of Ectoparasites on Rodents and Other Small Mammals. [PDF]

Bio Protoc
Yin PW, Guo XG, Song WY, Dong WG, Lv Y, Jin DC.   +5 more
europepmc   +1 more source

Mycobacterium leprae and Mycobacterium lepromatosis in small mammals in Midwest Brazil. [PDF]

Braz J Infect Dis
Nogueira BS, Maia MO, de Mendonça RFB, Nakazato L, Dutra V.   +4 more
europepmc   +1 more source

Small mammals and associated infections in China: a systematic review and spatial modelling analysis. [PDF]

Lancet Reg Health West Pac
Chen JJ, Lv CL, Wang T, Wang YH, Che TL, Xu Q, Hong XG, Teng AY, Tian S, Zhang YY, Liu MC, Wang LP, Hay SI, Yang Y, Fang LQ, Liu W.   +15 more
europepmc   +1 more source