Results 171 to 180 of about 194,605 (341)

Small-Molecule Positive Allosteric Modulators of theβ₂-Adrenoceptor Isolated from DNA-Encoded Libraries [PDF]

, 2018
Seungkirl Ahn, Biswaranjan Pani, Alem W. Kahsai, Eva K. Olsen, Gitte Husemoen, Mikkel Vestergaard, Lei Jin, Shuai Zhao, Laura M. Wingler, Paula Rambarat, Rishabh K. Simhal, Thomas T. Xu, Lillian Sun, Paul J. Shim, Dean P. Staus, Li-Yin Huang, Thomas Franch, Xin Chen, Robert J. Lefkowitz   +18 more
openalex   +1 more source

ePharmaLib: A Versatile Library of e-Pharmacophores to Address Small-Molecule (Poly-)Pharmacology

, 2022
Aurélien F. A. Moumbock, Jianyu Li, Hoai Thi Thu Tran, Hinkelmann Hinkelmann, Evelyn Lamy, Henning J. Jessen, Stefan Günther   +6 more
openalex   +2 more sources

Large‐Scale Interlaboratory Study Along the Entire Process Chain of Laser Powder Bed Fusion: Bridging Variability, Standards, and Optimization across Metals and Polymers

Advanced Engineering Materials, EarlyView.
What happens when 32 labs join forces to study nanoparticle‐modified powders? A data‐driven journey through laser powder bed fusion—now openly accessible for the entire additive manufacturing community—is studied. Laser powder bed fusion is a cornerstone technology for additive manufacturing (AM) of metals and polymers, yet challenges in achieving ...
Ihsan Murat Kuşoğlu, Sunidhi Garg, Arvid Abel, Prasanna V. Balachandran, Stephan Barcikowski, Louis Becker, Jan-Simeon Bernsmann, Jonas Boseila, Christoph Broeckmann, Mert Coskun, Malte Dreyer, Mark East, Mark Easton, Nils Ellendt, Stan Gann, Bilal Gökce, Mareen Goßling, Joachim Greiner, Piotr Gruber, Moritz Grünewald, Kopila Gurung, Nick Hantke, Florian Hengsbach, Hannes Holländer, Brecht Van Hooreweder, Kay-Peter Hoyer, Yajiang Huang, Florian Huber, Olaf Kessler, Burçin Özbay Kısasöz, Stefan Kleszczynski, Ebubekir Koc, Tomasz Kurzynowski, Arno Kwade, Simon Leupold, Dongmei Liu, Felix Lomo, Arne Lüddecke, Gerrit A. Luinstra, David A. Mauchline, Fabian Meyer, Lars Meyer, Peter Middendorf, Stefan Nolte, Michał Olejarczyk, Ludger Overmeyer, Andrij Pich, Sebastian Platt, Felix Radtke, Roland Ramm, Silja-Katharina Rittinghaus, Richard Rothfelder, Johannes Rudloff, Mirko Schaper, Marie Luise Scheck, Johannes Henrich Schleifenbaum, Michael Schmidt, Jan T. Sehrt, Yvonne P. Shabanga, Alexander Sommereyns, Rabea Steuer, Layla Shams Tisha, Anastasiya Toenjes, Christopher Tuck, Adrian Vaghar, Bey Vrancken, Zhengze Wang, Sebastian Weber, Jan Wegner, Bai-Xiang Xu, Yangyiwei Yang, Duyao Zhang, Evgeny Zhuravlev, Anna R. Ziefuss   +73 more
wiley   +1 more source

Chemical Space Overlap with Critical Protein-Protein Interface Residues in Commercial and Specialized Small-Molecule Libraries. [PDF]

ChemMedChem, 2019
Si Y, Xu D, Bum-Erdene K, Ghozayel MK, Yang B, Clemons PA, Meroueh SO.   +6 more
europepmc   +1 more source

Biologically‐Inspired Melt Electrowriting for the Generation of Highly Biomimetic Functional Myocardium

Advanced Functional Materials, EarlyView.
In this work, melt electrowriting is used to fabricate a 3D printed scaffold design that generates engineered cardiac tissues with in‐plane contraction, mimicking natural myocardium. It is shown that these tissues display advanced maturation and functionality.
Olalla Iglesias‐García, María Flandes‐Iparraguirre, Pilar Montero‐Calle, Ricardo M. Rosales, Asier Ullate‐Agote, Andrea Sánchez‐Bueno, Eduardo Larequi, Ilazki Anaut‐Lusar, Nicolás Laita, Aida Oliván‐Viguera, Elena Iglesias, Gloria Abizanda, Patxi San Martín‐Úriz, Paula Aguirre‐Ruiz, Xabier L. Aranguren, Manuel García de Yébenes, Juan José Gavira, Miguel Ángel Martínez, Estefanía Peña, Manuel Doblaré, Elena M. de‐Juan‐Pardo, Esther Pueyo, Felipe Prosper, Manuel M. Mazo Vega   +23 more
wiley   +1 more source

Optimization and development of a high-throughput TR-FRET screening assay for SLIT2/ROBO1 interaction

SLAS Discovery
The SLIT2/ROBO1 signaling axis plays a critical role in cell migration, angiogenesis, and immune regulation, contributing to tumor progression, metastasis, and therapy resistance.
Somaya A. Abdel-Rahman, Moustafa T. Gabr
doaj  

Electric Pulse Regulated MXene Based Nanozymes for Integrative Bioelectricity Immuno‐Cancer Therapy

Advanced Functional Materials, EarlyView.
MXenzyme‐mediated bioelectricity cancer therapy (MXenzyme‐BECT) enhances cancer cell death through irreversible depolarization, ion channel disruption, ROS generation, and immunogenic cell death. Computational simulations reveal the electrical mechanisms by which MXenzyme acts on single cells and support to predict treatment parameters. Next‐generation
Sanghee Lee, Seongchan Kim, Eui‐Sang Yu, Sian Lee, Min Jun Ko, Hyojin Lee, Dong‐Hyun Kim   +6 more
wiley   +1 more source

Polymer Brush Growth by Surface‐Initiated Ring‐Opening Polymerization from a Cross‐Linked Polymer Thin Film

Advanced Functional Materials, EarlyView.
A stable cross‐linked ultra‐thin polymer coating for surface‐initiated ring‐opening polymerization (SI‐ROP) of hexamethylcyclotrisiloxane and ε‐caprolactone for growth of high grafting density poly(dimethyl siloxane) and poly(caprolactone) brushes is developed.
Miguel Betancourt‐Ponce, Bharathan Govindarajan, Jacob Pike, Padma Gopalan   +3 more
wiley   +1 more source

Sensitive ADAR editing reporter in cancer cells enables high-throughput screening of small molecule libraries. [PDF]

Nucleic Acids Res, 2019
Fritzell K, Xu LD, Otrocka M, Andréasson C, Öhman M.   +4 more
europepmc   +1 more source

Biofilm Control by Active Topography with Mucin Coating

Advanced Functional Materials, EarlyView.
This study reports a new antifouling strategy based on a bioinspired design. Mucin coating enhances biofilm control by active topography with beating micron‐sized pillars. Besides the mechanical force of beating pillars, the antibiofilm activities also involve biological factors since mucin coating inhibits swarming motility and c‐di‐GMP synthesis in ...
Zehui Han, Yikang Xu, Huan Gu, Teng Zhang, Dacheng Ren   +4 more
wiley   +1 more source