Results 11 to 20 of about 194,605 (341)

Integrated Platform for Expedited Synthesis-Purification-Testing of Small Molecule Libraries. [PDF]

ACS Med Chem Lett, 2017
Baranczak A, Tu NP, Marjanovic J, Searle PA, Vasudevan A, Djuric SW.   +5 more
europepmc   +3 more sources

Phagemid Encoded Small Molecules for High Throughput Screening of Chemical Libraries [PDF]

Journal of the American Chemical Society, 2004
A new strategy for monovalently displaying small molecules on phage surfaces was developed and applied to high throughput screening for molecules with high binding affinity to the target protein. Peptidyl carrier protein (PCP) excised from nonribosomal peptide synthetase was monovalently displayed on the surface of M13 phage as pIII fusion proteins ...
Jun Yin, Fei Liu, Martina Schinke, Christian Daly, Christopher T. Walsh   +4 more
openalex   +4 more sources

High-throughput screening of small molecule libraries using SAMDI mass spectrometry. [PDF]

ACS Comb Sci, 2011
Gurard-Levin ZA, Scholle MD, Eisenberg AH, Mrksich M.   +3 more
europepmc   +3 more sources

Screening of Small-Molecule Libraries Using SARS-CoV-2-Derived Sequences Identifies Novel Furin Inhibitors. [PDF]

Int J Mol Sci
Jorkesh A, Rothenberger S, Baldassar L, Grybaite B, Kavaliauskas P, Mickevicius V, Dettin M, Vascon F, Cendron L, Pasquato A.   +9 more
europepmc   +3 more sources

Recent Advances in Divergent Synthetic Strategies for Indole-Based Natural Product Libraries

Molecules, 2022
Considering the potential bioactivities of natural product and natural product-like compounds with highly complex and diverse structures, the screening of collections and small-molecule libraries for high-throughput screening (HTS) and high-content ...
Taegwan Kim, Min Woo Ha, Jonghoon Kim
doaj   +1 more source

Highly parallel translation of DNA sequences into small molecules. [PDF]

PLoS ONE, 2012
A large body of in vitro evolution work establishes the utility of biopolymer libraries comprising 10(10) to 10(15) distinct molecules for the discovery of nanomolar-affinity ligands to proteins.
Rebecca M Weisinger, S Jarrett Wrenn, Pehr B Harbury   +2 more
doaj   +1 more source

Bloom filters for molecules

Journal of Cheminformatics, 2023
Ultra-large chemical libraries are reaching 10s to 100s of billions of molecules. A challenge for these libraries is to efficiently check if a proposed molecule is present. Here we propose and study Bloom filters for testing if a molecule is present in a
Jorge Medina, Andrew D. White
doaj   +1 more source

Discovery and Validation of a New Class of Small Molecule Toll-Like Receptor 4 (TLR4) Inhibitors [PDF]

, 2013
Many inflammatory diseases may be linked to pathologically elevated signaling via the receptor for lipopolysaccharide (LPS), toll-like receptor 4 (TLR4).
A Afrazi, A Afrazi, A Barochia, AG Rajapakse, Amin Afrazi, Benjamin Eyer, C Kunz, Chhinder P. Sodhi, Christopher J. Guerriero, CL Chen, CL Leaphart, Congrong Ma, CP Sodhi, D Awla, DA Johnson, David J. Hackam, ET Rietschel, F Souza-Fonseca-Guimaraes, FF Yuan, H Carlsen, HM Kim, Hongpeng Jia, J Neu, Jeffrey L. Brodsky, John Ozolek, KH Lee, KR Bortoluci, L Bode, L Bode, L Bode, M Ciszewicz, M Good, M Pierer, Maria Branca, Matthew D. Neal, MD Neal, Misty Good, MM Fort, Peter Wipf, R Medzhitov, S Sakai, S Sanlioglu, Samithamby Jeyaseelan, SC Gribar, T Jilling, Thomas Prindle, WK den Dekker, WM Richardson   +47 more
core   +5 more sources

Directed Chemical Evolution with an Outsized Genetic Code. [PDF]

PLoS ONE, 2016
The first demonstration that macromolecules could be evolved in a test tube was reported twenty-five years ago. That breakthrough meant that billions of years of chance discovery and refinement could be compressed into a few weeks, and provided a ...
Casey J Krusemark, Nicolas P Tilmans, Patrick O Brown, Pehr B Harbury   +3 more
doaj   +1 more source

Construction of a synthetic methodology-based library and its application in identifying a GIT/PIX protein–protein interaction inhibitor

Nature Communications, 2022
Chemical libraries with skeleton diversity are important for drug discovery. Here, the authors establish a synthetic methodology-based compound library (SMBL), and apply it to identify a small-molecule inhibitor to interrupt a challenging target:  the ...
Jing Gu, Rui-Kun Peng, Chun-Ling Guo, Meng Zhang, Jie Yang, Xiao Yan, Qian Zhou, Hongwei Li, Na Wang, Jinwei Zhu, Qin Ouyang   +10 more
doaj   +1 more source