Small-molecule discovery from DNA-encoded chemical libraries [PDF]
Chemical Society Reviews, 2011 Researchers seeking to improve the efficiency and cost effectiveness of the bioactive small-molecule discovery process have recently embraced selection-based approaches, which in principle offer much higher throughput and simpler infrastructure requirements compared with traditional small-molecule screening methods.
Kleiner, Ralph E. +2 more
openaire +5 more sources
DNA-Encoded Chemical Libraries: Advancing beyond Conventional Small-Molecule Libraries
Accounts of Chemical Research, 2014 ISSN:0001 ...
Franzini RM +2 more
semanticscholar +6 more sources
DNA-encoded libraries – an efficient small molecule discovery technology for the biomedical sciences [PDF]
Biological chemistry, 2018 DNA-encoded compound libraries are a highly attractive technology for the discovery of small molecule protein ligands. These compound collections consist of small molecules covalently connected to individual DNA sequences carrying readable information ...
Verena B. K. Kunig +3 more
semanticscholar +2 more sources
High-throughput screening of small molecule libraries using SAMDI mass spectrometry. [PDF]
ACS Comb Sci, 2011 High-throughput screening is a common strategy used to identify compounds that modulate biochemical activities, but many approaches depend on cumbersome fluorescent reporters or antibodies and often produce false-positive hits.
Gurard-Levin ZA +3 more
europepmc +2 more sources
Barcode-free hit discovery from massive libraries enabled by automated small molecule structure annotation [PDF]
Nature CommunicationsAffinity-selection platforms are powerful tools in early drug discovery, but current technologies – most notably DNA-encoded libraries (DELs) – are limited by synthesis complexity and incompatibility with nucleic acid-binding targets.
Edith van der Nol +14 more
doaj +2 more sources
Clustering Libraries of Compounds into Families: Asymmetry-Based Similarity Measure to Categorize Small Molecules [PDF]
, 2011 International audienceClustering Libraries of Compounds into Families: Asymmetry-Based Similarity Measure to Categorize Small ...
ACI, Samia +6 more
core +4 more sources
Completion of a programmable DNA-binding small molecule library [PDF]
Tetrahedron, 2007 Hairpin pyrrole-imidazole (Py-Im) polyamides are programmable oligomers that bind the DNA minor groove in a sequence-specific manner with affinities comparable to those of natural DNA-binding proteins. These cell-permeable small molecules have been shown to enter the nuclei of live cells and downregulate endogenous gene expression.
Hsu, Carey F. +9 more
openaire +4 more sources
Adhirons are efficient tools to guide antiviral ligand discovery [PDF]
Communications BiologyAdhirons are small, antibody-like proteins expressed in bacteria that bind to biological targets with high affinity. Since their discovery, Adhirons have been isolated against over 350 targets, and they can be used for many research applications. However,
Alex J. Flynn +5 more
doaj +2 more sources
Reporting data from high-throughput screening of small-molecule libraries [PDF]
Nature Chemical Biology, 2007 Publications reporting results of small-molecule screens are becoming more common as academic researchers increasingly make use of high-throughput screening (HTS) facilities. However, no standards have been formally established for reporting small-molecule screening data, and often key information important for the evaluation and interpretation of ...
James, Inglese +2 more
openaire +3 more sources
The evolution and application of RNA-focused small molecule libraries. [PDF]
RSC Chem BiolHits identified from screening diverse compound libraries against RNA targets can be used to inform design of RNA-focused libraries via computational techniques to calculate chemical similarity and physicochemical properties.
Taghavi A +6 more
europepmc +3 more sources