Advanced Healthcare Materials, EarlyView.Engineered 3D‐Cad/IL6‐MSC, developed through synergistic hE/N‐cad‐Fc and IL‐6 preconditioning, show remarkable therapeutic potential for systemic sclerosis. These engineered MSC aggregates reduce pathogenic inflammatory cell infiltration and restore immune balance among CD4+ T‐cell populations, offering a promising approach to optimize MSC based ...
Yue Zhang +11 more
wiley +1 more source
Screening of Small Molecule Interactor Library by Using In-Cell NMR Spectroscopy (SMILI-NMR) [PDF]
, 2009 Jingjing Xie +4 more
openalex +1 more source
Magnetic‐Driven Torque‐Induced Electrical Stimulation for Millisecond‐Scale Wireless Neuromodulation
Advanced Healthcare Materials, EarlyView.MagTIES is a wireless neuromodulation technique with millisecond precision. It employs magnetic‐driven torque from magnetite nanodiscs to activate piezoelectric nanoparticles, enabling precise temporal control of neuronal activity and brain oscillations using weak, low‐frequency magnetic fields.
Chao‐Chun Cheng +5 more
wiley +1 more source
Exploring chemical space for "druglike" small molecules in the age of AI. [PDF]
Front Mol BiosciKattuparambil AA +6 more
europepmc +1 more source
Advanced Healthcare Materials, EarlyView.This study presents a multiphasic bile duct construct composed of biocompatible materials and cells, featuring an inner layer that supports biliary epithelium growth, a middle layer providing mechanical strength, and an outer cell‐permissive layer designed to support future in vivo integration.
Mattia Pasqua +9 more
wiley +1 more source
PROFIS: Design of Target-Focused Libraries by Probing Continuous Fingerprint Space with Recurrent Neural Networks. [PDF]
J Chem Inf ModelRybka H, Danel T, Podlewska S.
europepmc +1 more source
Advanced Healthcare Materials, EarlyView.Imiquimod‐loaded nanoparticles (PFSUV‐IMQ) are found to decrease liver metastasis and liver tumor burden when administered intravenously. Flow cytometry, RNA‐seq and various experiments show that the anti‐tumor response is immune‐mediated by activating dendritic cells resulting in increased CD8 T cell infiltration and activity.
Vanessa Chan +13 more
wiley +1 more source
molli: A General-Purpose Python Toolkit for Combinatorial Small Molecule Library Generation, Manipulation, and Feature Extraction. [PDF]
Alexander S. Shved +5 more
openalex +1 more source
Comparative Metabolomics Reveals Biogenesis of Ascarosides, a Modular Library of Small-Molecule Signals in C. elegans [PDF]
, 2012 Stephan H. von Reuß +6 more
openalex +1 more source
Computational Simulations of Metal–Organic Frameworks to Enhance Adsorption Applications
Advanced Materials, EarlyView.This review highlights the significance of molecular simulations in expanding the understanding of metal–organic frameworks (MOFs) and improving their gas adsorption applications. The historical development and implementation of molecular simulations in the MOF field are given, high‐throughput computational screening studies used to unlock the ...
Hilal Daglar +3 more
wiley +1 more source