Results 31 to 40 of about 645,880 (357)
Plant chemical genetics : from phenotype-based screens to synthetic biology [PDF]
, 2017 The treatment of a biological system with small molecules to specifically perturb cellular functions is commonly referred to as chemical biology. Small molecules are used commercially as drugs, herbicides, and fungicides in different systems, but in ...
Dejonghe, Wim, Russinova, Eugenia
core +3 more sources
Química Nova, 2001 Combinatorial Chemistry has become a very efficient methodology in drug research. Recent progress in combinatorial synthesis performed both in solid and solution phase have led to a change in the paradigm for the identification and optimization of lead ...
Ricardo L. Araújo Dias +1 more
doaj +1 more source
Impact of DNA-Encoded Chemical Library Technology on Drug Discovery
CHIMIA, 2022 DNA-Encoded Chemical Libraries (DELs) have gained momentum over the recent years for the discovery of small-molecule ligands and the technology has been integrated in most of the larger pharmaceutical companies.
Michelle Keller +2 more
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Deep learning to generate in silico chemical property libraries and candidate molecules for small molecule identification in complex samples. [PDF]
Analytical Chemistry, 2019 Comprehensive and unambiguous identification of small molecules in complex samples will revolutionize our understanding of the role of metabolites in biological systems.
S. Colby +4 more
semanticscholar +1 more source
Indolinyl-Thiazole Based Inhibitors of Scavenger Receptor-BI (SR-BI)-Mediated Lipid Transport [PDF]
, 2014 A potent class of indolinyl-thiazole based inhibitors of cellular lipid uptake mediated by scavenger receptor, class B, type I (SR-BI) was identified via a high-throughput screen of the National Institutes of Health Molecular Libraries Small Molecule ...
Bennion, Melissa +18 more
core +3 more sources
NeuralDock: Rapid and Conformation-Agnostic Docking of Small Molecules
Frontiers in Molecular Biosciences, 2022 Virtual screening is a cost- and time-effective alternative to traditional high-throughput screening in the drug discovery process. Both virtual screening approaches, structure-based molecular docking and ligand-based cheminformatics, suffer from ...
Congzhou M. Sha +6 more
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Frontiers in Pharmacology, 2023 Virtual small molecule libraries are valuable resources for identifying bioactive compounds in virtual screening campaigns and improving the quality of libraries in terms of physicochemical properties, complexity, and structural diversity.
Fernanda I. Saldívar-González +2 more
doaj +1 more source
Elimination of PCR duplicates in RNA-seq and small RNA-seq using unique molecular identifiers
BMC Genomics, 2018 Background RNA-seq and small RNA-seq are powerful, quantitative tools to study gene regulation and function. Common high-throughput sequencing methods rely on polymerase chain reaction (PCR) to expand the starting material, but not every molecule ...
Yu Fu +4 more
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Exploring the Phytochemical Landscape of the Early-Diverging Flowering Plant Amborella trichopoda Baill. [PDF]
, 2019 Although the evolutionary significance of the early-diverging flowering plant Amborella (Amborella trichopoda Baill.) is widely recognized, its metabolic landscape, particularly specialized metabolites, is currently underexplored.
Chang, Lijing +3 more
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Stem Cells Translational Medicine, 2020 Identification of small molecules with the potential to selectively proliferate cardiac progenitor cells (CPCs) will aid our understanding of the signaling pathways and mechanisms involved and could ultimately provide tools for regenerative therapies for
Lauren Drowley +14 more
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