Results 31 to 40 of about 194,605 (341)

Allosteric “beta-blocker” isolated from a DNA-encoded small molecule library [PDF]

, 2017
The present study reports the discovery of a small-molecule negative allosteric modulator for the β2-adrenergic receptor (β2AR) via in vitro affinity-based iterative selection of highly diverse DNA-encoded small-molecule libraries.
Ahn, Seungkirl, Bassoni, Daniel L., Burnett, Michael B., Chen, Xin, Cho, Ted, Choi, Minjung, Costanzi, Stefano, Franch, Thomas, Gavino, Bryant J., Hansen, Gwenn M., Husemoen, Gitte, Kahsai, Alem W., Lamerdin, Jane E., Lefkowitz, Robert J., Olsen, Eva K., Pani, Biswaranjan, Sinnaeve, Justine, Staus, Dean P., Strachan, Ryan T., Sun, Lillian D., Wall, Alissa L., Wang, Qin-Ting, Wingler, Laura M., Xu, Thomas T., Zhao, Shuai   +24 more
core   +2 more sources

Indolinyl-Thiazole Based Inhibitors of Scavenger Receptor-BI (SR-BI)-Mediated Lipid Transport [PDF]

, 2014
A potent class of indolinyl-thiazole based inhibitors of cellular lipid uptake mediated by scavenger receptor, class B, type I (SR-BI) was identified via a high-throughput screen of the National Institutes of Health Molecular Libraries Small Molecule ...
Bennion, Melissa, Dandapani, Sivaraman, Dockendorff, Chris, Faloon, Patrick W., Krieger, Monty, Lam, Garrett, Lewis, Timothy A., Munoz, Benito, Nag, Partha P., Negri, Joseph, Nieland, Thomas J.F., Palmer, Michelle A., Paterson, Conor, Penman, Marsha, Perez, José R., Pu, Jun, Schreiber, Stuart L., Youngsaye, Willmen, Yu, Miao   +18 more
core   +3 more sources

Small Molecule Library Synthesis Using Segmented Flow

Molecules, 2011
Flow chemistry has gained considerable recognition as a simple, efficient, and safe technology for the synthesis of many types of organic and inorganic molecules ranging in scope from large complex natural products to silicon nanoparticles. In this paper we describe a method that adapts flow chemistry to the synthesis of libraries of compounds using a ...
Jeffrey L. Cross, Irini Akritopoulou-Zanze, Stevan W. Djuric, Jennifer L. Poole, Christina M. Thompson   +4 more
openaire   +3 more sources

Identification of Small Molecule Inhibitors of Clostridium perfringens ε-Toxin Cytotoxicity Using a Cell-Based High-Throughput Screen

Toxins, 2010
The Clostridium perfringens epsilon toxin, a select agent, is responsible for a severe, often fatal enterotoxemia characterized by edema in the heart, lungs, kidney, and brain. The toxin is believed to be an oligomeric pore-forming toxin.
Mark S. McClain, Michelle Lewis, Charles David Weaver   +2 more
doaj   +1 more source

An ultra high-throughput, whole-animal screen for small molecule modulators of a specific genetic pathway in Caenorhabditis elegans. [PDF]

PLoS ONE, 2013
High-throughput screening (HTS) is a powerful approach to drug discovery, but many lead compounds are found to be unsuitable for use in vivo after initial screening. Screening in small animals like C.
Chi K Leung, Ying Wang, Siobhan Malany, Andrew Deonarine, Kevin Nguyen, Stefan Vasile, Keith P Choe   +6 more
doaj   +1 more source

Benzo-fused Lactams from a Diversity-oriented Synthesis (DOS) Library as Inhibitors of Scavenger Receptor BI (SR-BI)-mediated Lipid Uptake [PDF]

, 2015
We report a new series of 8-membered benzo-fused lactams that inhibit cellular lipid uptake from HDL particles mediated by Scavenger Receptor, Class B, Type I (SR-BI).
Bennion, Melissa, Dandapani, Sivaraman, Dockendorff, Chris, Faloon, Patrick W., Johnston, Stephen, Krieger, Monty, Munoz, Benito, Nieland, Thomas J.F., Palmer, Michelle A., Penman, Marsha, Perez, José R., Pu, Jun, Schreiber, Stuart L., Yu, Miao   +13 more
core   +2 more sources

Identification of Inhibitors of Integrin Cytoplasmic Domain Interactions With Syk

Frontiers in Immunology, 2021
Leukocyte inflammatory responses require integrin cell-adhesion molecule signaling through spleen tyrosine kinase (Syk), a non-receptor kinase that binds directly to integrin β-chain cytoplasmic domains.
Deenadayalan Bakthavatsalam, John W. Craft, John W. Craft, Anna Kazansky, Nghi Nguyen, Goeun Bae, Amy R. Caivano, C. William Gundlach, Asra Aslam, Safa Ali, Shashikant Gupta, Sophie Y. Lin, Hema D. Parthiban, Peter Vanderslice, Clifford C. Stephan, Darren G. Woodside   +15 more
doaj   +1 more source

Discovery of Bisamide-heterocycles as Inhibitors of Scavenger Receptor BI (SR-BI)-mediated Lipid Uptake [PDF]

, 2015
A new series of potent inhibitors of cellular lipid uptake from HDL particles mediated by scavenger receptor, class B, type I (SR-BI) was identified. The series was identified via a high-throughput screen of the National Institutes of Health Molecular ...
Bennion, Melissa, Dandapani, Sivaraman, Dockendorff, Chris, Faloon, Patrick W., Germain, Andrew, Krieger, Monty, Munoz, Benito, Nag, Partha P., Nieland, Thomas J.F., Palmer, Michelle A., Penman, Marsha, Perez, José R., Schreiber, Stuart L., Youngsaye, Willmen, Yu, Miao   +14 more
core   +2 more sources

FERM3D: A finite element R-matrix electron molecule scattering code [PDF]

, 2006
FERM3D is a three-dimensional finite element program, for the elastic scattering of a low energy electron from a general polyatomic molecule, which is converted to a potential scattering problem.
Allan, Bathe, Bouchiha, Boudaiffa, Colle, Dill, Gianturco, Gianturco, Gianturco, Gianturco, Gianturco, Gibson, Granovsky, Greene, Hara, Lane, Lee, Lehoucq, Li, Lucchese, Lucchese, McCall, Morrison, Morrison, Pople, Press, Rescigno, Scheer, Stefano Tonzani, Tennyson, Tonzani, Tonzani, Tonzani, Tonzani, Trevisan, Werner   +35 more
core   +2 more sources

Exploring the Phytochemical Landscape of the Early-Diverging Flowering Plant Amborella trichopoda Baill. [PDF]

, 2019
Although the evolutionary significance of the early-diverging flowering plant Amborella (Amborella trichopoda Baill.) is widely recognized, its metabolic landscape, particularly specialized metabolites, is currently underexplored.
Chang, Lijing, Tian, Li, Wilson, Alexander E, Wu, Sheng   +3 more
core   +1 more source