Results 141 to 150 of about 442,180 (329)
SNHG25 facilitates SNORA50C accumulation to stabilize HDAC1 in neuroblastoma cells
Cell Death and Disease, 2022 Increasing studies have pointed out that small nucleolar RNAs (snoRNAs) and their host genes (SNHGs) have multi-functional roles in cancer progression. Bioinformatics analysis revealed the importance of snoRNA host gene 25 (SNHG25) in neuroblastoma (NB).
Huijuan Zeng +10 more
doaj +1 more source
rDNA Copy Number Variation and Methylation During Normal and Premature Aging
Aging Cell, Volume 24, Issue 5, May 2025.In > 160 healthy individuals the absolute rDNA copy number (CN) in blood ranged from approximately 240 to 900. The number of active copies with a completely unmethylated promoter varied from 40 to 120, independent of absolute CN. Promoter methylation is a compensation mechanism for absolute CN variation. Aging was associated with a loss of unmethylated
Alva B. C. Geisen +5 more
wiley +1 more source
Precursors to the U3 Small Nucleolar RNA Lack Small Nucleolar RNP Proteins but Are Stabilized by La Binding [PDF]
Molecular and Cellular Biology, 2000 Almost all small eukaryotic RNAs are processed from transiently stabilized 3'-extended forms. A key question is how and why such intermediates are stabilized and how they can then be processed to the mature RNA. Here we report that yeast U3 is also processed from a 3'-extended precursor.
Kufel, J +5 more
openaire +4 more sources
Yeast snR30 Is a Small Nucleolar RNA Required for 18S rRNA Synthesis [PDF]
, 1993 John P. Morrissey, David Tollervey
openalex +2 more sources
Aging Cell, Volume 24, Issue 5, May 2025.We show that genetic and pharmacological inhibition of the metabotropic glutamate receptor, DmGluRA extends Drosophila lifespan, improves stress tolerance and alters early‐life locomotion. Several markers indicative of reduced ribosomal biogenesis, a hallmark of longevity, were also detected in these flies.
Cui Guan +4 more
wiley +1 more source
Characterization of nuclear polyadenylated RNA-binding proteins in Saccharomyces cerevisiae. [PDF]
, 1994 To study the functions of heterogeneous nuclear ribonucleoproteins (hnRNPs), we have characterized nuclear polyadenylated RNA-binding (Nab) proteins from Saccharomyces cerevisiae.
Datar, KV +4 more
core +1 more source
Age‐Dependent Clonal Expansion of Non–Sperm‐Forming Spermatogonial Stem Cells in Mouse Testes
Aging Cell, EarlyView.We found that GFRα1+ spermatogonial stem cells (SSCs) with reduced Egr4 and Cops5 expression did not form spermatids in mouse testes. Furthermore, the proportion of their clones relative to the total SSC clones increased and their distribution area expanded in old mice.
Terumichi Kawahara +10 more
wiley +1 more source
Small nucleolar RNAs functioning and potential roles in cancer
Tumor Biology, 2014 Non-coding RNAs (ncRNAs) are important regulatory molecules involved in various physiological and pathological cellular processes. Small nucleolar RNAs (snoRNAs), subclass of small ncRNAs, have been considered important but unglamorous elements in the production of protein synthesis machinery of cells.
Thorenoor, Nithyananda, Slaby, Ondrej
openaire +2 more sources
The site of ribonucleic acid synthesis in the isolated nucleus [PDF]
, 1961 There is still controversy concerning the primary site of RNA synthesis in the cell.(1) When tissues are radioautographed after administration of radioactive inorganic phosphorus or radioactive RNA(2) precursors such as tritiated uridine or cytidine, it ...
Bonner, James, Rho, Joon H.
core
A snoRNA modulates mRNA 3' end processing and regulates the expression of a subset of mRNAs. [PDF]
, 2017 mRNA 3' end processing is an essential step in gene expression. It is well established that canonical eukaryotic pre-mRNA 3' processing is carried out within a macromolecular machinery consisting of dozens of trans-acting proteins. However, it is unknown
Ding, Junjun +14 more
core +1 more source