Results 131 to 140 of about 60,360 (226)
The Critical Role of GALNTs‐Regulated O‐GalNAc Glycosylation in Cancer Malignancy
The FASEB Journal, Volume 40, Issue 8, 30 April 2026.The GALNT family initiates mucin‐type O‐GalNAc glycosylation in the Golgi apparatus and how regulatory mechanisms, including GALNT relocalization and microRNA control, modulate this process. Dysregulated O‐GalNAc glycosylation alters key cellular behaviors and promotes cancer malignancy, highlighting its relevance to tumor progression as well as its ...
Jiahao Liu +7 more
wiley +1 more source
The hidden regulators: Non‐coding RNAs in KMT2A‐rearranged acute lymphoblastic leukemia
International Journal of Cancer, Volume 158, Issue 8, Page 2003-2012, 15 April 2026.Abstract Acute lymphoblastic leukemia (ALL) driven by KMT2A rearrangements (KMT2A‐r) is an aggressive hematologic malignancy with poor prognosis and a high incidence in infants. While KMT2A fusion proteins drive leukemogenesis through transcriptional dysregulation, recent discoveries have highlighted the pivotal role of non‐coding RNAs (ncRNAs) in ...
Maria Augusta Poersch +5 more
wiley +1 more source
Mammalian Small Nucleolar RNAs Are Mobile Genetic Elements
PLoS Genetics, 2005 Small nucleolar RNAs (snoRNAs) of the H/ACA box and C/D box categories guide the pseudouridylation and the 2'-O-ribose methylation of ribosomal RNAs by forming short duplexes with their target. Similarly, small Cajal body-specific RNAs (scaRNAs) guide modifications of spliceosomal RNAs. The vast majority of vertebrate sno/scaRNAs are located in introns
openaire +4 more sources
Circulating pancreatic cancer exosomal RNAs for detection of pancreatic cancer
Molecular Oncology, 2019 Diagnostic biomarkers for the early diagnosis of pancreatic cancer are needed to improve prognosis for this disease. The aim of this study was to investigate differences in the expression of four messenger RNAs (mRNAs: CCDC88A, ARF6, Vav3, and WASF2) and
Tatsuya Kitagawa +6 more
doaj +1 more source
Nature CommunicationsIntrinsically disordered regions (IDRs) are highly enriched in the nucleolar proteome but their physiological role in ribosome assembly remains poorly understood.
Carine Dominique +14 more
doaj +1 more source
Recent advances of SNHG in regulating mesenchymal stem cell osteogenic differentiation
Kouqiang hemian waike zazhiBone healing and bore regeneration are complex processes in maintaining normal bone homeostasis. Mesenchymal stem cells are main resource of osteoblasts that are responsible for bone formation.
HUANG Jie, WANG Zuolin
doaj +1 more source
International Journal of Cardiology: Heart & VasculatureIntroduction: Oxygen therapy does not benefit normoxemic patients with suspected myocardial infarction and may instead enhance the inflammatory response triggered by the tissue necrosis caused by the myocardial infarction. In the present study, we tested
P. Tornvall +6 more
doaj +1 more source
Quantitative studies of hepatocytes in periportal and perivenous zones of the liver lobules in diabetic rats [PDF]
, 2007 This study was designed to evaluate the morphometric changes of parenchymal cells in the periportal (Z1) and perivenous (Z3) zones of the liver lobules that occur after Streptozotocin-induced diabetes in rats.
Ghafari, S., Golalipour, M.J.
core
Nuclear export factor 3 regulates localization of small nucleolar RNAs [PDF]
, 2017 Lee, Jiyeon +6 more
core +2 more sources
BiomoleculesSmall nucleolar RNAs (snoRNAs) and their host genes (SNHGs) are non-coding RNAs that are integral to tumorigenesis and progression. snoRNAs contribute to tumor progression primarily through RNA modification and engagement in intracellular signaling, and ...
Jiaji Yu, Yingjie Shao, Wendong Gu
doaj +1 more source