Results 151 to 160 of about 62,138 (272)

Disruption of the l‐DOPA Receptor Gpr143/OA1‐Gene in Mice Creates a Unique Mixed Psychosis‐Like Phenotype

open access: yesNeuropsychopharmacology Reports, Volume 46, Issue 1, March 2026.
We analyzed the behavior of GPR143 gene‐deficient mice. GPR143‐KO mice displayed a mixed psychiatric phenotype. GPR143 may play a role in mesolimbic and mesocortical functions underlying sensory gating, reward, social hierarchy, cognition, and emotional regulation. ABSTRACT GPR143, originally identified as the gene product of ocular albinism 1 (OA1), a
Yoshio Goshima   +9 more
wiley   +1 more source

Targeting aerobic glycolysis combats tyrosine kinase inhibitor resistance of hepatocellular carcinoma

open access: yesInternational Journal of Cancer, Volume 158, Issue 3, Page 475-487, 1 February 2026.
Abstract Hepatocellular carcinoma (HCC) represents the predominant form of primary liver cancer and is frequently identified at a late stage, necessitating systemic therapy. However, resistance to first‐line tyrosine kinase inhibitor therapies, such as sorafenib and lenvatinib, remains a significant clinical challenge.
Longtao Zhao   +6 more
wiley   +1 more source

A Cellular and Transcriptomic Atlas of the Aged Mouse Hematopoietic System

open access: yesAging Cell, Volume 25, Issue 2, February 2026.
Transcriptomic and cellular atlas of peripheral blood mononuclear cells (PBMCs) and stem and progenitor cells of the hematopoietic compartment (HSPCs) of aged C57Bl/6J mice. Analysis shows global alterations related to immune function and identifies potential pathways and cell populations that can be targeted for therapeutic intervention.
Ryan R. White   +9 more
wiley   +1 more source

ICSH Recommendations for Monocyte Cell Lineage Morphologic Identification, Nomenclature Harmonization, and Utilization as a Biomarker

open access: yesInternational Journal of Laboratory Hematology, Volume 48, Issue 1, Page 12-25, February 2026.
ABSTRACT Monocytes are key components of the Mononuclear Phagocyte System, crucial in immune defense, inflammation, and tissue repair. Accurate identification and classification of monocyte lineage cells are essential for diagnosing both reactive and clonal hematologic disorders.
Gina Zini   +10 more
wiley   +1 more source

The dual life of disordered lysine-rich domains of snoRNPs in rRNA modification and nucleolar compaction

open access: yesNature Communications
Intrinsically disordered regions (IDRs) are highly enriched in the nucleolar proteome but their physiological role in ribosome assembly remains poorly understood.
Carine Dominique   +14 more
doaj   +1 more source

Recent advances of SNHG in regulating mesenchymal stem cell osteogenic differentiation

open access: yesKouqiang hemian waike zazhi
Bone healing and bore regeneration are complex processes in maintaining normal bone homeostasis. Mesenchymal stem cells are main resource of osteoblasts that are responsible for bone formation.
HUANG Jie, WANG Zuolin
doaj   +1 more source

Mining Potential Therapeutic Targets for T Cell Exhaustion in Osteoarthritis by Integrating Mendelian Randomization and Single‐Cell Sequencing

open access: yesThe FASEB Journal, Volume 40, Issue 2, 31 January 2026.
This study conducted an integrated analysis using multi‐source data, with specific data sources including the GEO database (encompassing datasets GSE55235, GSE55457, and GSE152805), literature‐mined gene sets, and the IEU OpenGWAS database (dataset ebi‐a‐GCST005814).
Jiahong Li   +9 more
wiley   +1 more source

Live‐Cell RNA Imaging via Clickable TriPPPro Nucleotide Reporters

open access: yesAngewandte Chemie International Edition, Volume 65, Issue 2, 9 January 2026.
The intracellular delivery of trans‐cyclooctene and bicyclo[6.1.0]nonyne as sterically demanding groups for the inverse electron‐demand Diels–Alder was achieved by the triphosphate prodrug (TriPPPro) strategy. Once hydrolyzed inside cells, the modified uridines and cytidines are metabolically incorporated into nascent RNA, are labelled by a dual ...
J. Iven H. Knaack   +6 more
wiley   +1 more source

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