Results 151 to 160 of about 442,180 (329)

RNA as a Permutation [PDF]

arXiv, 2014
RNA secondary structure prediction and classification are two important problems in the field of RNA biology. Here, we propose a new permutation based approach to create logical non-disjoint clusters of different secondary structures of a single class or type. Many different types of techniques exist to classify RNA secondary structure data but none of
arxiv  

microRNAs may sharpen spatial expression patterns [PDF]

, 2007
The precise layout of gene expression patterns is a crucial step in development. Formation of a sharp boundary between high and low expression domains requires a genetic mechanism which is both sensitive and robust to fluctuations, a demand that may not be easily achieved by morphogens alone.
arxiv   +1 more source

Nuclear Import Defects Drive Cell Cycle Dysregulation in Neurodegeneration

Aging Cell, EarlyView.
Overview of Dysregulated Cell Cycle Mechanisms in Neuronal Cells. A nuclear import block drives cell cycle re‐entry from G0, culminating in cell cycle arrest at G1/S. This cell cycle arrest is associated with activation of CKIs from the INK locus (p15, p16, p18, p19) and Cip/Kip (p21, p27) which act on specific CDK/Cyclin complexes.
Jonathan Plessis‐Belair, Taylor Russo, Markus Riessland, Roger B. Sher   +3 more
wiley   +1 more source

Dual Requirement for Yeast hnRNP Nab2p in mRNA poly(A) Tail Length Control and Nuclear Export [PDF]

, 2002
Recent studies of mRNA export factors have provided additional evidence for a mechanistic link between mRNA 3′‐end formation and nuclear export. Here, we identify Nab2p as a nuclear poly(A)‐binding protein required for both poly(A) tail length control ...
Anderson, James T., Dheur, Sonia, Hector, Ronald E., Minvielle‐Sebastia, Lionel, Non, Priscilla J., Nykamp, Keith R., Swanson, Maurice S., Urbinati, Carl R., Wilson, Scott M.   +8 more
core   +3 more sources

Mean diameter of nucleolar bodies in cultured human leukemic myeloblasts is mainly related to the S and G2 phase of the cell cycle

European Journal of Histochemistry, 2009
Mean diameter of nucleolar bodies (nucleoli without the perinucleolar chromatin) per cell was studied in human leukemic myeloblasts represented by K 562 and Kasumi 1 cell lines which originated from chronic and acute myeloid leukaemia. The measurement of
K Smetana, K Kuželová, M Zápotocky, J Starková, Z Hrkal, J Trka   +5 more
doaj   +1 more source

HN1 Functions in Protein Synthesis Regulation via mTOR‐RPS6 Axis and Maintains Nucleolar Integrity

Cell Proliferation, EarlyView.
HN1 is required for nucleolar homeostasis which is the site of ribosome biogenesis and protein synthesis when its mRNA is knocked down by shRNA, it depletes in cytoplasm and the protein synthesis is downregulated in comparison to controls. Thus, the proliferating cells requiring vast number of nucleosomes, are arrested at S onset.
Gülseren Özduman, Aadil Javed, Azime Akçaöz Alasar, Bünyamin Akgül, Kemal Sami Korkmaz   +4 more
wiley   +1 more source

Drosophila CG3303 is an essential endoribonuclease linked to TDP-43-mediated neurodegeneration [PDF]

, 2017
Endoribonucleases participate in almost every step of eukaryotic RNA metabolism, acting either as degradative or biosynthetic enzymes. We previously identified the founding member of the Eukaryotic EndoU ribonuclease family, whose components display ...
BOZZONI, Irene, CAFFARELLI, ELISA, CAPAUTO, DAVIDE, CAPPUCCI, UGO, CASALE, ASSUNTA MARIA, DI CARLO, VALERIO, DI FRANCO, Carmela Antonia, DI MICCO, PATRIZIO, GIOIA, UBALDO, LANEVE, Pietro, Morea, Veronica, PIACENTINI, Lucia   +11 more
core   +1 more source

A Robust and Precise ConvNet for small non-coding RNA classification (RPC-snRC) [PDF]

arXiv, 2019
Functional or non-coding RNAs are attracting more attention as they are now potentially considered valuable resources in the development of new drugs intended to cure several human diseases. The identification of drugs targeting the regulatory circuits of functional RNAs depends on knowing its family, a task which is known as RNA sequence ...
arxiv  

IMPDH2's Central Role in Cellular Growth and Diseases: A Potential Therapeutic Target

Cell Proliferation, EarlyView.
IMPDH2 is a rate‐limiting enzyme in guanine nucleotide biosynthesis. It plays diverse roles in various physiological and pathological processes: nucleotide metabolism, inflammation, immune function, ribosomal stress. Structural or regulatory alterations in IMPDH2 are linked to significant health issues, and critical relevance in disease progression. We
Zheng Li, Yunpeng Zou, Jiayao Niu, Ying Zhang, Aohua Yang, Wenyu Lin, Jie Guo, Shuya Wang, Ronghan Liu   +8 more
wiley   +1 more source

Force Unfolding Single RNAs: from Equilibrium to Far-from Equilibrium [PDF]

arXiv, 2005
We summarize the recent simulation progress of micromanipulation experiments on RNAs. Our work mainly consults with two important small RNAs unfolding experiments carried out by Bustamante group. Our results show that, in contrast to protein cases, using the single polymer elastic theory and the well known RNA secondary structure free energy knowledge,
arxiv