Results 51 to 60 of about 1,233,249 (248)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Singularly perturbed linear oscillator with piecewise-constant argument

Вестник КазНУ. Серия математика, механика, информатика, 2018
The Cauchy problem for singularly perturbed linear differential equation the second order with piecewise-constant argument is considered in the article.
M. U. Akhmet, M. K. Dauylbayev, A. E. Mirzakulova, N. Atakhan   +3 more
doaj   +1 more source

The reflecting function and the small parameter method

Applied Mathematics Letters, 2008
The aim of this work is to combine the method of the reflecting function and the perturbation method to obtain sufficient conditions for the existence of a family of periodic solutions close to a given solution for multidimensional autonomous and non-autonomous differential systems.
openaire   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Some estimates for the viscoelastic incompressible Kelvin-Voigt medium

Қарағанды университетінің хабаршысы. Математика сериясы
In this paper, we consider the application of the method of fictitious domains to a viscoelastic incompressible medium based on the Kelvin-Voigt model.
M.M. Bukenov, D.S. Rakisheva
doaj   +1 more source

An asymptotic solution for the SIS epidemic model, taking into account migration and diffusion [PDF]

Известия высших учебных заведений: Прикладная нелинейная динамика
The purpose of this work is to propose and investigate a simple and effective model of an epidemic in an animal population that takes into account migration along the plane of both diseased and healthy individuals. Within the framework of this model, the
Rassadin, Aleksandr Eduardovich
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Analysis of Running Waves Stability in the Ginzburg-Landau Equation with Small Diffusion

Моделирование и анализ информационных систем, 2011
We study the local dynamics of the Ginzburg-Landau equation with small diffusion in a neibourhood of running waves. We find necessary conditions of running waves instability and sufficient conditions of their stability.
A. A. Kashchenko
doaj  

Study of Stress-Strain State of Long Cracked Multi-Modulus Strip in Bending in Relation to Crack Formation in Tensile Zone of Concrete

Structural Mechanics of Engineering Constructions and Buildings
The problem of strength analysis of a multi-modulus strip, in contradiction to the existing standpoint of essential nonlinearity, may be formulated as a linear problem for a two-layer strip.
Evgeniy M. Zveryaev
doaj   +1 more source