Results 71 to 80 of about 1,233,249 (248)
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
Generalized Pad´e approximations in the problem of calculating the period of a relaxation cycle
Вестник Самарского университета: Естественнонаучная серияWhen solving many applied problems, it is necessary to calculate the bifurcation values of the parameters of a dynamical system. These values must be determined with a high degree of accuracy. As a rule, bifurcation parameter values are found in the form
E. S. Dolgova
doaj +1 more source
An approximate group classification of a perturbed subdiffusion equation
Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2016 A problem of the Lie point approximate symmetry group classification of a perturbed subdiffusion equation with a small parameter is solved. The classification is performed with respect to anomalous diffusion coefficient which is considered as a function ...
Stanislav Yu Lukashchuk
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Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Small-x evolution of jet quenching parameter
Physics Letters B, 2015 Concept of transverse deflection probability of a parton that travels through strongly interacting medium, recently introduced by D'Eramo, Liu and Rajagopal, have been used to derive high energy evolution equation for the jet quenching parameter in stochastic multiple scatterings regime. Jet quenching parameter, ${\hat q}(x)$, appears to evolve with $x$
openaire +4 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Pseudodifferential operators with generalized symbols and regularity theory
Electronic Journal of Differential Equations, 2005 We study pseudodifferential operators with amplitudes $a_varepsilon (x,xi)$ depending on a singular parameter $varepsilon o 0$ with asymptotic properties measured by different scales.
Claudia Garetto +2 more
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