Results 61 to 70 of about 1,176,120 (248)

Reducing Friction with a Liquid Film on the Body Surface

open access: yesLubricants, 2018
A flow of a thin layer of liquid is simulated on a flat surface of a body located in a stream of air. Liquid film on the surface of the body reduces frictional resistance and can be used as a boundary layer control element.
Nikolay Klyuev   +2 more
doaj   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Random Homogenization in a Domain with Light Concentrated Masses

open access: yesMathematics, 2020
In the paper, we consider an elliptic problem in a domain with singular stochastic perturbation of the density located near the boundary, depending on a small parameter.
Gregory A. Chechkin   +1 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Economical Numerical-Analytical Method for Calculating Three-Dimensional Deformations of Elastic Pipes of Variable Cross Section

open access: yesМеханика машин, механизмов и материалов, 2017
In this paper it is shown that the problem of quasistatic three-dimensional stress-strain state of elastic pipes of a variable cross-section under the influence of internal pressure can be solved economically and quickly by a numerical-analytical rapid ...
Nikolay G. Burago, Ilya S. Nikitin
doaj  

Some scenarios for delaying the loss of stability in differential systems with multiscale variables

open access: yesВестник Самарского университета: Естественнонаучная серия
The paper is devoted to a detailed study of the mechanism of stability loss in dynamical systems with fast and slow variables. The need for such research arises in various applied problems, in particular, in connection with the study of combustion, and ...
O. S. Kipkaeva, E. A. Shchepakina
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

An approximate group classification of a perturbed subdiffusion equation

open access: yesVestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2016
A problem of the Lie point approximate symmetry group classification of a perturbed subdiffusion equation with a small parameter is solved. The classification is performed with respect to anomalous diffusion coefficient which is considered as a function ...
Stanislav Yu Lukashchuk
doaj   +1 more source

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