Results 91 to 100 of about 4,398,040 (341)

On a multipoint nonlocal initial value problem for a singularly-perturbed first-order ODE [PDF]

E-Journal of Analysis and Applied Mathematics, 2019
A linear first order ordinary differential equation (ODE) with a positive parameter $\varepsilon$ and a multipoint nonlocal initial value condition (NLIVC) is considered.
Dovlet M. Dovletov
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Possibility to measure thermal effects in the Casimir force

, 2010
We analyze the possibility to measure small thermal effects in the Casimir force between metal test bodies in configurations of a sphere above a plate and two parallel plates.
B. Geyer, E. M. Lifshitz, E. M. Lifshitz, E. M. Lifshitz, G. L. Klimchitskaya, H. B. G. Casimir, I. E. Dzyaloshinskii, K. A. Milton, M. Bordag, M. Krech, P. W. Milonni, V. M. Mostepanenko, V. M. Mostepanenko   +12 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Reducing Friction with a Liquid Film on the Body Surface

Lubricants, 2018
A flow of a thin layer of liquid is simulated on a flat surface of a body located in a stream of air. Liquid film on the surface of the body reduces frictional resistance and can be used as a boundary layer control element.
Nikolay Klyuev, Konstantin Polyakov, Alyona Krutovertseva   +2 more
doaj   +1 more source

Random Homogenization in a Domain with Light Concentrated Masses

Mathematics, 2020
In the paper, we consider an elliptic problem in a domain with singular stochastic perturbation of the density located near the boundary, depending on a small parameter.
Gregory A. Chechkin, Tatiana P. Chechkina   +1 more
doaj   +1 more source

Impact of small scale inhomogeneities on observations of standard candles

, 2014
We investigate the effect of small scale inhomogeneities on standard candle observations, such as type Ia supernovae (SNe) observations. Existence of the small scale inhomogeneities may cause a tension between SNe observations and other observations with
Iwata, Kengo, Yoo, Chul-Moon
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

A New Parametrization of the Neutrino Mixing Matrix

, 2004
The neutrino mixing matrix is expanded in powers of a small parameter $\lambda$, which approximately equals to 0.1. The meaning of every order of the expansion is discussed respectively, and the range of $\lambda$ is carefully calculated. We also present
Ahmad, Ahmad, Ahn, Altarelli, Apollonio, Bilenky, Bo-Qiang Ma, Boehm, Cabibbo, Eguchi, Gilman, Guo, Jarlskog, Jarlskog, Jung, Kobayashi, Maki, Maltoni, Nan Li, Schechter, Schechter, Schechter, Schechter, Wolfenstein, Wolfenstein, Xing   +25 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source