Results 91 to 100 of about 1,233,249 (248)
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Small dark energy without small parameters
, 2017 We present a prototype model that resolves the cosmological constant problem using matter alone, i.e., without modifying gravity. Its generic cosmological solutions adjust an arbitrarily large, negative dark energy to a positive value parametrically suppressed by an initial field velocity.
openaire +2 more sources
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Механика машин, механизмов и материалов, 2017 In this paper it is shown that the problem of quasistatic three-dimensional stress-strain state of elastic pipes of a variable cross-section under the influence of internal pressure can be solved economically and quickly by a numerical-analytical rapid ...
Nikolay G. Burago, Ilya S. Nikitin
doaj
Some scenarios for delaying the loss of stability in differential systems with multiscale variables
Вестник Самарского университета: Естественнонаучная серияThe paper is devoted to a detailed study of the mechanism of stability loss in dynamical systems with fast and slow variables. The need for such research arises in various applied problems, in particular, in connection with the study of combustion, and ...
O. S. Kipkaeva, E. A. Shchepakina
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Asymptotic Expansion Method with Respect to Small Parameter for Ternary Diffusion Models. [PDF]
Interdiscip Sci, 2017 Danielewski M +2 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source