Results 91 to 100 of about 1,176,120 (248)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Generalized Pad´e approximations in the problem of calculating the period of a relaxation cycle
Вестник Самарского университета: Естественнонаучная серияWhen solving many applied problems, it is necessary to calculate the bifurcation values of the parameters of a dynamical system. These values must be determined with a high degree of accuracy. As a rule, bifurcation parameter values are found in the form
E. S. Dolgova
doaj +1 more source
Small dark energy without small parameters
, 2017 We present a prototype model that resolves the cosmological constant problem using matter alone, i.e., without modifying gravity. Its generic cosmological solutions adjust an arbitrarily large, negative dark energy to a positive value parametrically suppressed by an initial field velocity.
openaire +2 more sources
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Қарағанды университетінің хабаршысы. Математика сериясыThe article is devoted to the study of a singularly perturbed initial problem for a linear differential equation with a piecewise constant argument second-order for a small parameter.
A.E. Mirzakulova, K.T. Konisbayeva
doaj +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Asymptotic Expansion Method with Respect to Small Parameter for Ternary Diffusion Models. [PDF]
Interdiscip Sci, 2017 Danielewski M +2 more
europepmc +1 more source