Results 31 to 40 of about 2,560,191 (266)

Targeting MicroRNAs with Small Molecules

Non-Coding RNA
MicroRNAs (miRs) have been implicated in numerous diseases, presenting an attractive target for the development of novel therapeutics. The various regulatory roles of miRs in cellular processes underscore the need for precise strategies. Recent advances in RNA research offer hope by enabling the identification of small molecules capable of selectively ...
Kisanet Tadesse, Raphael I. Benhamou
openaire   +3 more sources

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

Research on Pedestrian Detection Model and Compression Technology for UAV Images

Sensors, 2022
The large view angle and complex background of UAV images bring many difficulties to the detection of small pedestrian targets in images, which are easy to be detected incorrectly or missed. In addition, the object detection models based on deep learning
Xihao Liu, Chengbo Wang, Li Liu
doaj   +1 more source

Targeting Large and Small [PDF]

Optik & Photonik, 2009
AbstractA corporation that grows dynamically through acquisition needs two good strategies for success: one for the growth itself and one for the integration of the acquired companies. The positive development of the fiber optics business unit within the Leoni group suggests that the management has set the right course for the future.
openaire   +1 more source

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Small Ship Detection Based on Improved Neural Network Algorithm and SAR Images

Remote Sensing
Synthetic aperture radar images can be used for ship target detection. However, due to the unclear ship outline in SAR images, noise and land background factors affect the difficulty and accuracy of ship (especially small target ship) detection ...
Jiaqi Li, Hongyuan Huo, Li Guo, De Zhang, Wei Feng, Yi Lian, Long He   +6 more
doaj   +1 more source

SegDetector: A Deep Learning Model for Detecting Small and Overlapping Damaged Buildings in Satellite Images

Remote Sensing, 2022
Buildings bear much of the damage from natural disasters, and determining the extent of this damage is of great importance to post-disaster emergency relief.
Zhengbo Yu, Zhe Chen, Zhongchang Sun, Huadong Guo, Bo Leng, Ziqiong He, Jinpei Yang, Shuwen Xing   +7 more
doaj   +1 more source

Targeted Protein Degradation by Small Molecules [PDF]

Annual Review of Pharmacology and Toxicology, 2017
Protein homeostasis networks are highly regulated systems responsible for maintaining the health and productivity of cells. Whereas therapeutics have been developed to disrupt protein homeostasis, more recently identified techniques have been used to repurpose homeostatic networks to effect degradation of disease-relevant proteins.
Daniel P, Bondeson, Craig M, Crews
openaire   +2 more sources

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Image-Level Anti-Personnel Landmine Detection Using Deep Learning in Long-Wave Infrared Images

Applied Sciences
This study proposes a simple deep learning-based framework for image-level anti-personnel landmine detection in long-wave infrared imagery. To address challenges posed by the limited size of the available dataset and the small spatial size of anti ...
Jun-Hyung Kim, Goo-Rak Kwon
doaj   +1 more source