Results 31 to 40 of about 15,598 (248)

Targeting DNA-Protein Crosslinks via Post-Translational Modifications

Frontiers in Molecular Biosciences, 2022
Covalent binding of proteins to DNA forms DNA-protein crosslinks (DPCs), which represent cytotoxic DNA lesions that interfere with essential processes such as DNA replication and transcription.
Xueyuan Leng, Julien P. Duxin
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Rapid identification of ubiquitination and SUMOylation target sites by microfluidic peptide array

Biochemistry and Biophysics Reports, 2016
SUMOylation and ubiquitination are two essential post translational modifications (PTMs) involved in the regulation of important biological processes in eukaryotic cells.
Bing Zhu, Tierra R. Farris, Sarah L. Milligan, Haosi Chen, Ruijuan Zhu, Aailing Hong, Xiaochuan Zhou, Xiaolian Gao, Jere W. McBride   +8 more
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The emerging roles of SUMOylation in the tumor microenvironment and therapeutic implications

Experimental Hematology & Oncology, 2023
Tumor initiation, progression, and response to therapies depend to a great extent on interactions between malignant cells and the tumor microenvironment (TME), which denotes the cancerous/non-cancerous cells, cytokines, chemokines, and various other ...
Yunru Gu, Yuan Fang, Xi Wu, Tingting Xu, Tong Hu, Yangyue Xu, Pei Ma, Qiang Wang, Yongqian Shu   +8 more
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Profiling the Murine SUMO Proteome in Response to Cardiac Ischemia and Reperfusion Injury

Molecules, 2020
SUMOylation is a reversible posttranslational modification pathway catalyzing the conjugation of small ubiquitin-related modifier (SUMO) proteins to lysine residues of distinct target proteins.
Paul W. Hotz, Marion Wiesnet, Georg Tascher, Thomas Braun, Stefan Müller, Luca Mendler   +5 more
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Antigenicity and Immunogenicity Analysis of the E. coli Expressed FMDV Structural Proteins; VP1, VP0, VP3 of the South African Territories Type 2 Virus

Viruses, 2021
An alternative vaccine design approach and diagnostic kits are highly required against the anticipated pandemicity caused by the South African Territories type 2 (SAT2) Foot and Mouth Disease Virus (FMDV).
Guoxiu Li, Ashenafi Kiros Wubshet, Yaozhong Ding, Qian Li, Junfei Dai, Yang Wang, Qian Hou, Jiao Chen, Bing Ma, Anna Szczotka-Bochniarz, Susan Szathmary, Yongguang Zhang, Jie Zhang   +12 more
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NopD of Bradyrhizobium sp. XS1150 Possesses SUMO Protease Activity

Frontiers in Microbiology, 2020
Effectors secreted by the type III protein secretion system (T3SS) of rhizobia are host-specific determinants of the nodule symbiosis. Here, we have characterized NopD, a putative type III effector of Bradyrhizobium sp. XS1150.
Qi-Wang Xiang, Juan Bai, Jie Cai, Qin-Ying Huang, Yan Wang, Ying Liang, Zhi Zhong, Christian Wagner, Zhi-Ping Xie, Christian Staehelin   +9 more
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Using dot blot with immunochemical detection to evaluate global changes in SUMO-2/3 conjugation

BioTechniques, 2012
Small ubiquitin-related modifier-2/3 (SUMO-2/3) is a member of the ubiquitin-like (Ubl) protein family. Conjugation of SUMO-2/3 to target proteins is influenced by various stress conditions and chemical inhibitors.
Markéta Častorálová, Tomáš Ruml, Zdeněk Knejzlík   +2 more
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SUMOylation is required for optimal TRAF3 signaling capacity. [PDF]

PLoS ONE, 2013
TNF receptor-associated factors (TRAFs) are multifunctional adaptor proteins involved in temporal and spatial coordination of signals necessary for normal immune function.
Sophia Miliara, Kalliopi K Gkouskou, Tyson V Sharp, Aristides G Eliopoulos   +3 more
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SUMO modulation of protein aggregation and degradation

AIMS Molecular Science, 2015
Small ubiquitin-like modifier (SUMO) conjugation and binding to target proteins regulate a wide variety of cellular pathways. The functional aspects of SUMOylation include changes in protein-protein interactions, intracellular trafficking as well as ...
Marco Feligioni, Serena Marcelli, Erin Knock, Urooba Nadeem, Ottavio Arancio, Paul E. Fraser   +5 more
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Influence of Sox protein SUMOylation on neural development and regeneration

Neural Regeneration Research, 2022
SRY-related HMG-box (Sox) transcription factors are known to regulate central nervous system development and are involved in several neurological diseases.
Kun-Che Chang
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