Results 221 to 230 of about 10,358,075 (261)

ASSOCIATION BETWEEN CEREBRAL SMALL VESSEL DISEASE AND ALZHEIMER'S DISEASE PATHOLOGIES

Cerebral Circulation - Cognition and Behavior
Yuan Cai, Wanting Liu, Xiang Fan, Lin Shi, Lisa Wing Chi Au, Bonnie Yin Ka Lam, Jill Abrigo, Vincent Chung Tong Mok   +7 more
doaj   +1 more source

Arterial Spin Labeling Hemodynamic Indices Relate to Cognitive and Small Vessel Disease Trajectories Over 11 Years. [PDF]

Stroke
Robb WH, Santner AM, Zhang P, Kim DS, Jackson TB, Shashikumar N, Pechman KR, Vyas Y, Liu D, Davis LT, Hohman TJ, Jefferson AL.   +11 more
europepmc   +1 more source

Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid‐Beta Pathology in Alzheimer's Mice

Advanced Science, EarlyView.
Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu, Jihua Fan, Xiang Zhou, Zhiqi Yang, Mingyue Gong, Mingzhu Huang, Zhenlu Cai, Shaofan Yang, Teng Teng, Chuanyan Yang, Jin Li, Haoyu Wang, Shuangshuang Dai, Chunhai Chen, Xiaowei Chen, Manxia Wang, Kuan Zhang   +16 more
wiley   +1 more source

White matter hyperintensity drives EEG microstate abnormalities in arteriosclerotic cerebral small vessel disease. [PDF]

Front Neurosci
Feng K, Cai J, Lei J, Zeng G, Chen H, Chen J, He Q, Liang L, Li Y, Zhang X, Li H, Ye S.   +11 more
europepmc   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Chinese medicine interventions for cerebral small vessel disease-related cognitive impairment: a systematic review and meta-analysis. [PDF]

Front Pharmacol
Zhao M, Zheng X, Mu Y, Zhang G, Lai X.
europepmc   +1 more source

Dual‐Organelle Secretome Conjugation and Organ‐Uptake Tracking (DuO‐SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins

Advanced Science, EarlyView.
A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...
Fenglian Yang, Rui Qian, Jiaxing Song, Xingqi Meng, Jin Young Kim, Kwok On Lai, Li Wang, Liang Zhang   +7 more
wiley   +1 more source

Cerebral Artery Pulsatility, Premorbid Blood Pressure, and Small Vessel Disease on Brain Imaging: A Population-Based Study. [PDF]

Neurology
Li L, Mazzucco S, Lau GKK, Tuna MA, Rothwell PM.   +4 more
europepmc   +1 more source

SR‐A3 Promotes USP18‐Mediated deISGylation of STING to Protect Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Yufei Han, Guolin Miao, Yinqi Zhao, Zhiyong Du, Kaikai Lu, Changqi Xiao, Aiden Xian, Jiaxin Duanmu, Zihao Zhou, Jinxuan Chen, Lianxin Zhang, Chao Zhai, Yitong Xu, Zhaoling Li, Xianqin Shen, Sijing Shi, Jingxuan Chen, Si Mei, Yuan Fang, Liwen Zheng, Ling Zhang, Yuhui Wang, Wei Huang, Erdan Dong, Xunde Xian   +24 more
wiley   +1 more source

Oral microbiota dysbiosis related to the cortical thinning and cognitive impairment in cerebral small vessel disease. [PDF]

J Oral Microbiol
Lizhu Y, Chen Y, Zhang X, Luo Y, Zhuo Z, Wang J, Duan Y, Chai L, Qiu J, Gao Z, Wang T, Yan H, Liang X, Wang Y, Su Y, Guan L, Liu Y.   +16 more
europepmc   +1 more source