Results 21 to 30 of about 1,093,638 (350)

Cerebral small vessel disease: Pathological mechanisms and potential therapeutic targets

Frontiers in Aging Neuroscience, 2022
Cerebral small vessel disease (CSVD) represents a diverse cluster of cerebrovascular diseases primarily affecting small arteries, capillaries, arterioles and venules.
Yue Gao, Di Li, Jianwen Lin, Aline M. Thomas, Jianyu Miao, Dong Chen, Shen Li, Chengyan Chu   +7 more
semanticscholar   +1 more source

Advanced MRI in cerebral small vessel disease

International Journal of Stroke, 2022
Cerebral small vessel disease (cSVD) is a major cause of stroke and dementia. This review summarizes recent developments in advanced neuroimaging of cSVD with a focus on clinical and research applications.
H. van den Brink, F. Doubal, M. Duering
semanticscholar   +1 more source

Cerebral Small Vessel Disease and Chronic Kidney Disease [PDF]

Journal of Stroke, 2015
Chronic kidney disease, defined by a decreased glomerular filtration rate or albuminuria, is recognized as a major global health burden, mainly because it is an established risk factor for cardiovascular and cerebrovascular diseases. The magnitude of the
Kazunori Toyoda
doaj   +1 more source

Cerebral small vessel disease and vascular cognitive impairment: from diagnosis to management

Current Opinion in Neurology, 2021
Purpose of review We present recent developments in the field of small vessel disease (SVD)-related vascular cognitive impairment, including pathological mechanisms, updated diagnostic criteria, cognitive profile, neuroimaging markers and risk factors ...
M.C. Zanon Zotin, L. Sveikata, A. Viswanathan, P. Yilmaz   +3 more
semanticscholar   +1 more source

ESO Guideline on covert cerebral small vessel disease

European Stroke Journal, 2021
‘Covert’ cerebral small vessel disease (ccSVD) is common on neuroimaging in persons without overt neurological manifestations, and increases the risk of future stroke, cognitive impairment, dependency, and death.
J. Wardlaw, S. Debette, H. Jokinen, F. de Leeuw, L. Pantoni, H. Chabriat, J. Staals, F. Doubal, S. Rudilosso, Sebastian Eppinger, Sabrina Schilling, R. Ornello, C. Enzinger, C. Cordonnier, M. Taylor-Rowan, A. Lindgren   +15 more
semanticscholar   +2 more sources

Microglial activation and blood–brain barrier permeability in cerebral small vessel disease

Brain : a journal of neurology, 2021
See Edison (doi:10.1093/brain/awab149) for a scientific commentary on this article. Using advanced brain imaging techniques, Walsh et al. provide evidence of both neuroinflammation and increased blood-brain barrier permeability in patients with cerebral ...
J. Walsh, D. Tozer, H. Sari, Young T. Hong, A. Drazyk, Guy B. Williams, N. Shah, J. O'Brien, F. Aigbirhio, G. Rosenberg, T. Fryer, H. Markus   +11 more
semanticscholar   +1 more source

Framework for Clinical Trials in Cerebral Small Vessel Disease (FINESSE): A Review.

JAMA Neurology, 2022
Importance Cerebral small vessel disease (SVD) causes a quarter of strokes and is the most common pathology underlying vascular cognitive impairment and dementia. An important step to developing new treatments is better trial methodology.
H. Markus, W. M. van der Flier, E. Smith, P. Bath, G. Biessels, E. Briceño, Amy Brodtman, H. Chabriat, Christopher P L H Chen, F. de Leeuw, M. Egle, A. Ganesh, Marios K. Georgakis, R. Gottesman, S. Kwon, L. Launer, Vincent C. T. Mok, J. O'Brien, Lois Ottenhoff, S. Pendlebury, E. Richard, P. Sachdev, R. Schmidt, Melanie Springer, Stefan Tiedt, J. Wardlaw, A. Verdelho, A. Webb, D. Werring, M. Duering, D. Levine, M. Dichgans   +31 more
semanticscholar   +1 more source

Inflammatory biomarkers and cerebral small vessel disease: a community-based cohort study

Stroke and vascular neurology, 2022
Background and purpose Although inflammation has been proposed to be a candidate risk factor for cerebral small vessel disease (CSVD), previous findings remain largely inconclusive and vary according to disease status and study designs. The present study
Dingding Zhang, Yuan Cao, Jingwei Mu, Yiming Liu, F. Gao, F. Han, F. Zhai, Li-xin Zhou, J. Ni, M. Yao, Ming-Li Li, Z. Jin, Shu-yang Zhang, L. Cui, Yong Shen, Yicheng Zhu   +15 more
semanticscholar   +1 more source

Disentangling the effects of Alzheimer’s and small vessel disease on white matter fibre tracts

Brain : a journal of neurology, 2022
Alzheimer’s disease and cerebral small vessel disease are the two leading causes of cognitive decline and dementia and coexist in most memory clinic patients.
Anna Dewenter, Mina A. Jacob, Mengfei Cai, B. Gesierich, Paul Hager, Anna Kopczak, D. Biel, M. Ewers, A. Tuladhar, F. de Leeuw, M. Dichgans, N. Franzmeier, M. Duering   +12 more
semanticscholar   +1 more source

Cerebral small vessel disease burden and cognitive and functional outcomes after stroke: A multicenter prospective cohort study

Alzheimer's & Dementia, 2022
It remains unknown whether the global small vessel disease (SVD) burden predicts post‐stroke outcomes.
Marios K. Georgakis, Rong Fang, M. Düring, F. Wollenweber, F. Bode, Sebastian Stösser, Christine Kindlein, Peter Hermann, T. Liman, C. Nolte, Lucia Kerti, B. Ikenberg, Kathleen Bernkopf, H. Poppert, W. Glanz, V. Perosa, D. Janowitz, Michael Wagner, K. Neumann, O. Speck, L. Dobisch, E. Düzel, B. Gesierich, Anna Dewenter, A. Spottke, K. Waegemann, M. Görtler, S. Wunderlich, M. Endres, I. Zerr, G. Petzold, M. Dichgans   +31 more
semanticscholar   +1 more source