Results 61 to 70 of about 125,699 (320)
Dynamic Cap‐Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease
Advanced Science, EarlyView.The first crystal structure of MPXV I7L protease, revealing its unique dimeric form is resolved. The structures and MD simulations uncovered a dynamic cap region that regulates substrate access to the active site. The structural basis of substrate recognition and the catalytic mechanism are elucidated, which led to the development of a FRET‐based assay
Haixia Su +12 more
wiley +1 more source
Multifaceted contributions : health workers and smallpox eradication in India [PDF]
, 2008 Smallpox eradication in South Asia was a result of the efforts of many grades of health-workers. Working from within the confines of international organisations and government structures, the role of the field officials, who were of various nationalities
Banerji D. +25 more
core +3 more sources
Emerging Microbes and InfectionsA large outbreak of monkeypox occurred in 2022, and most people lack immunity to orthopoxvirus. Smallpox vaccination is essential for preventing further smallpox outbreaks.
Hao Liu +7 more
doaj +1 more source
Advanced NanoBiomed Research, EarlyView.Chemically modified graphene oxide nanocarriers provide a targeted lung cancer gene therapy platform. In a 3D tumor microenvironment model, these nanocarriers deliver therapeutic genes, regulate immune markers, and induce apoptosis in cancer cells. Combined gene delivery enhances cancer cell elimination, demonstrating the potential of this approach for
Francesca Grilli +3 more
wiley +1 more source
A Recent Survey of the Advancements in Deep Learning Techniques for Monkeypox Disease Detection [PDF]
arXiv, 2023 Monkeypox (MPox) is a zoonotic infectious disease induced by the MPox Virus, part of the poxviridae orthopoxvirus group initially discovered in Africa and gained global attention in mid-2022 with cases reported outside endemic areas. Symptoms include headaches, chills, fever, smallpox, measles, and chickenpox-like skin manifestations and the WHO ...
arxiv
Populations Addressed in Vaccines Approved via the European Medicines Agency
Clinical Pharmacology &Therapeutics, EarlyView.Therapeutic and prophylactic agents require robust evidence before patient use. Randomized controlled trials are essential for evaluating safety and efficacy but often exclude specific populations that are also targets for the intervention. This study assessed which populations are included in vaccine registration studies and/or addressed in label ...
Débora D. Gräf +3 more
wiley +1 more source
Smallpox and Bioterrorism: Why the Plan to Protect the Nation Is Stalled and What to Do [PDF]
, 2003 The Iraq war is over, no weapons of mass destruction (WMD) have yet been found, and the president's smallpox plan, though sound, is running out of steam. Instead of being well on the way to protecting the nation's civilian population by vaccinating up to
Kenneth D. Bloem, William J. Bicknell
core
A generalized-growth model to characterize the early ascending phase of infectious disease outbreaks [PDF]
, 2016 A better characterization of the early growth dynamics of an epidemic is needed to dissect the important drivers of disease transmission. We introduce a 2-parameter generalized-growth model to characterize the ascending phase of an outbreak and capture ...
Chowell, Gerardo +2 more
core +4 more sources
ChemPhotoChem, EarlyView.This review summarizes recent progress in chalcogen (S, Se, Te)‐incorporated photosensitizers and photothermal agent design. It explores synthetic strategies, spectroscopic and computational characterization, and in vitro/in vivo evaluations, showcasing the potential of these compounds for photodynamic and photothermal therapies.
Subhrakant Jena +3 more
wiley +1 more source