Results 41 to 50 of about 14,512 (186)

Rethinking Smallpox [PDF]

open access: yesClinical Infectious Diseases, 2004
The potential consequences of a competently executed smallpox attack have not been adequately considered by policy makers. The possibility of release of an aerosolized and/or bioengineered virus must be anticipated and planned for. The transmission and infectivity of variola virus are examined.
Martin M, Weiss   +3 more
openaire   +2 more sources

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

open access: yesAdvanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang   +12 more
wiley   +1 more source

Critical role of perforin-dependent CD8+ T cell immunity for rapid protective vaccination in a murine model for human smallpox [PDF]

open access: yes, 2012
Vaccination is highly effective in preventing various infectious diseases, whereas the constant threat of new emerging pathogens necessitates the development of innovative vaccination principles that also confer rapid protection in a case of emergency ...
Gerd Sutter (181175)   +37 more
core   +2 more sources

The Role of Brincidofovir in Preparation for a Potential Smallpox Outbreak

open access: yesViruses, 2017
Smallpox (variola) virus is considered a Category A bioterrorism agent due to its ability to spread rapidly and the high morbidity and mortality rates associated with infection. Current recommendations recognize the importance of oral antivirals and call
Scott A. Foster   +2 more
doaj   +1 more source

Monkeypox Goes North: Ongoing Worldwide Monkeypox Infections in Humans

open access: yesViruses, 2022
In the late 1970s, global vaccination programs resulted in the eradication of smallpox. The Monkeypox virus (MPXV), which is closely related to the smallpox-inducing variola virus, was previously endemic only in Sub-Saharan Africa but is currently ...
Barbara S. Schnierle
doaj   +1 more source

Membranous dysmenorrhea and decidual casts: A scoping review

open access: yesInternational Journal of Gynecology &Obstetrics, EarlyView.
Abstract Background Membranous dysmenorrhea, characterized by the expulsion of intact endometrial tissue rather than gradual dissolution during menstruation, occasionally presents as a decidual cast—a complete triangular mold of the uterine cavity. This poorly understood condition is likely underdiagnosed.
Lovisa Brehmer, Hedvig Engberg
wiley   +1 more source

Vaccination in pediatric transplantation—General recommendations. A position paper by the European Reference Network TransplantChild

open access: yesJournal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Infectious diseases remain a leading cause of morbidity and mortality among pediatric transplant recipients, despite significant advances in transplantation management. Vaccination is the most effective strategy to prevent infections; however, its efficacy is hindered in solid organ transplant (SOT) and hematopoietic stem cell transplant (HSCT)
Valeria Casotti   +35 more
wiley   +1 more source

Global perspectives on smallpox vaccine against monkeypox: a comprehensive meta-analysis and systematic review of effectiveness, protection, safety and cross-immunogenicity

open access: yesEmerging Microbes and Infections
A large outbreak of monkeypox occurred in 2022, and most people lack immunity to orthopoxvirus. Smallpox vaccination is essential for preventing further smallpox outbreaks.
Hao Liu   +7 more
doaj   +1 more source

Rethinking the History of Smallpox in the Early Twentieth Century: The and Uncertainty Surrounding the Diagnosis of Smallpox [PDF]

open access: yesUisahak, 2020
This research explores the case of the 1903 smallpox outbreak on the SS Korea, a transpacific carrier making runs between Southeast Asia, East Asia, Hawaii, and the United States.
Hyon Ju LEE
doaj   +1 more source

Pietro Verri: The History of Smallpox Vaccination Through His Pencil

open access: yesJEADV Clinical Practice, EarlyView.
ABSTRACT The last case of natural smallpox infection occurred in 1977, and the disease is considered eradicated since 1980. Throughout the history of medicine, early attempts to combat smallpox involved inoculation, a practice based on the observation that those who recovered from the disease became immune.
Omar Simonetti   +5 more
wiley   +1 more source

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