Results 31 to 40 of about 103,751 (236)

Comparative virology and pathology of Monkeypox virus in Syrian hamsters, C57BL/6, and BALB/c mice: A framework for preclinical model selection

Animal Models and Experimental Medicine, EarlyView.
This study compared monkeypox virus (MPXV) infection in three small animal models: Syrian hamsters, C57BL/6 mice, and BALB/c mice. Following intraperitoneal inoculation, Syrian hamsters exhibited the highest susceptibility, with rapid systemic viral dissemination, elevated splenic and renal viral burdens, and severe histopathological damage, followed ...
Xiaohui Wei, Jing Wu, Hekai Yang, Na Li, Binbin Zhao, Wanjun Peng, Na Rong, Wei Zhang, Jing Xue, Jiangning Liu   +9 more
wiley   +1 more source

Smallpox and Bioterrorism: Why the Plan to Protect the Nation Is Stalled and What to Do [PDF]

, 2003
The Iraq war is over, no weapons of mass destruction (WMD) have yet been found, and the president's smallpox plan, though sound, is running out of steam. Instead of being well on the way to protecting the nation's civilian population by vaccinating up to
Kenneth D. Bloem, William J. Bicknell
core  

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

Teaching a new mouse old tricks: Humanized mice as an infection model for Variola virus.

PLoS Pathogens, 2021
Smallpox, caused by the solely human pathogen Variola virus (VARV), was declared eradicated in 1980. While known VARV stocks are secure, smallpox remains a bioterrorist threat agent. Recent U.S. Food and Drug Administration approval of the first smallpox
Christina L Hutson, Ashley V Kondas, Jana M Ritter, Zachary Reed, Sharon Dietz Ostergaard, Clint N Morgan, Nadia Gallardo-Romero, Cassandra Tansey, Matthew R Mauldin, Johanna S Salzer, Christine M Hughes, Cynthia S Goldsmith, Darin Carroll, Victoria A Olson   +13 more
doaj   +1 more source

Monkeypox Goes North: Ongoing Worldwide Monkeypox Infections in Humans

Viruses, 2022
In the late 1970s, global vaccination programs resulted in the eradication of smallpox. The Monkeypox virus (MPXV), which is closely related to the smallpox-inducing variola virus, was previously endemic only in Sub-Saharan Africa but is currently ...
Barbara S. Schnierle
doaj   +1 more source

Smallpox Revisited? [PDF]

The American Journal of Bioethics, 2003
This article reviews the history of smallpox and ethical issues that arise with its threat as a biological weapon. Smallpox killed more people than any infectious disease in history--and perhaps three times more people in the 20th Century than were killed by all the wars of that period.
openaire   +3 more sources

Global perspectives on smallpox vaccine against monkeypox: a comprehensive meta-analysis and systematic review of effectiveness, protection, safety and cross-immunogenicity

Emerging Microbes and Infections
A large outbreak of monkeypox occurred in 2022, and most people lack immunity to orthopoxvirus. Smallpox vaccination is essential for preventing further smallpox outbreaks.
Hao Liu, Wenjing Wang, Yang Zhang, Fuchun Wang, Junyi Duan, Tao Huang, Xiaojie Huang, Tong Zhang   +7 more
doaj   +1 more source

The Role of Brincidofovir in Preparation for a Potential Smallpox Outbreak

Viruses, 2017
Smallpox (variola) virus is considered a Category A bioterrorism agent due to its ability to spread rapidly and the high morbidity and mortality rates associated with infection. Current recommendations recognize the importance of oral antivirals and call
Scott A. Foster, Scott Parker, Randall Lanier   +2 more
doaj   +1 more source

Evolution of means and principles of smallpox vaccination

Вестник войск РХБ защиты, 2020
There are several possible reasons for the return of smallpox as an endemic disease. For example, the possibility of maintaining smallpox virus in an active state in the corpses of the dead, buried in permafrost regions, or the evolutionary changes of ...
S. V. Borisevich, V. N. Podkuyko, A. P. Pirozhkov, A. I. Terent'ev, V. P. Krasnyansky, E. V. Rozhdestvensky, S. V. Nazarov, S. V. Kuznecov   +7 more
doaj   +1 more source

Dynamics of multi-stage infections on networks [PDF]

, 2015
This paper investigates the dynamics of infectious diseases with a nonexponentially distributed infectious period. This is achieved by considering a multistage infection model on networks. Using pairwise approximation with a standard closure, a number of
AJ Black, AL Lloyd, AL Lloyd, CA Donnelly, CT Bauch, D Anderson, DR Cox, DT Gillespie, E Kenah, EH Kaplan, G Chowell, HJ Wearing, HTH Nguyen, HW Hethcote, I. Z. Kiss, J Ma, JC Miller, JM Hyman, JP Koplan, K Sharkey, K. B. Blyuss, KB Blyuss, KTD Eames, KTD Eames, L Danon, M Newman, M Newman, M Taylor, MEJ Newman, MI Meltzer, MJ Keeling, MJ Keeling, MJ Keeling, MJ Keeling, MJ Keeling, N MacDonald, N. Sherborne, NM Ferguson, NM Ferguson, NTJ Bailey, O Diekmann, O Diekmann, P Driessche van den, P Rattana, R Durrett, RE Hope-Simpson, RM Anderson, S Bansal, S Boccaletti, S Cauchemez, S Funk, S Riley, T House, T House, T House, TL Burr, V Andreasen, W Kermack, W-Y Chen, Z Feng   +59 more
core   +2 more sources