Results 11 to 20 of about 103,751 (236)

The origins and genomic diversity of American Civil War Era smallpox vaccine strains

Genome Biology, 2020
Vaccination has transformed public health, most notably including the eradication of smallpox. Despite its profound historical importance, little is known of the origins and diversity of the viruses used in smallpox vaccination.
Ana T. Duggan, Jennifer Klunk, Ashleigh F. Porter, Anna N. Dhody, Robert Hicks, Geoffrey L. Smith, Margaret Humphreys, Andrea M. McCollum, Whitni B. Davidson, Kimberly Wilkins, Yu Li, Amanda Burke, Hanna Polasky, Lowell Flanders, Debi Poinar, Amogelang R. Raphenya, Tammy T. Y. Lau, Brian Alcock, Andrew G. McArthur, G. Brian Golding, Edward C. Holmes, Hendrik N. Poinar   +21 more
doaj   +1 more source

Remaining Questions about Clinical Variola Major

Emerging Infectious Diseases, 2011
After the recent summary of World Health Organization–authorized research on smallpox, several clinical issues remain. This policy review addresses whether early hemorrhagic smallpox is disseminated intravascular coagulation and speculates about the ...
J. Michael Lane
doaj   +1 more source

Urban inoculation and the decline of smallpox mortality in eighteenth-century cities-a reply to Razzell. [PDF]

, 2015
Smallpox was probably the single most lethal disease in eighteenth-century Britain but was reduced to a minor cause of death by the mid-nineteenth century due to vaccination programmes post-1798.
Boulton, Jeremy, Davenport, Romola J, Schwarz, Leonard   +2 more
core   +2 more sources

Progression of pathogenic events in cynomolgus macaques infected with variola virus. [PDF]

PLoS ONE, 2011
Smallpox, caused by variola virus (VARV), is a devastating human disease that affected millions worldwide until the virus was eradicated in the 1970 s.
Victoria Wahl-Jensen, Jennifer A Cann, Kathleen H Rubins, John W Huggins, Robert W Fisher, Anthony J Johnson, Fabian de Kok-Mercado, Thomas Larsen, Jo Lynne Raymond, Lisa E Hensley, Peter B Jahrling   +10 more
doaj   +1 more source

Struggling to a monumental triumph : Re-assessing the final stages of the smallpox eradication program in India, 1960-1980 [PDF]

, 2007
The global smallpox program is generally presented as the brainchild of a handful of actors from the WHO headquarters in Geneva and at the agency's regional offices.
Basu, R. N, Bonne W, Bonne W, Brilliant L. B, Brilliant L. B, Dutta Mahendra, Dutta Mahendra, Grasset N, Grasset N, Grasset N, Grasset N, Grasset N, Grasset N. c, Greenough P, Gunaratne V.T.H, Henderson D.A, Henderson D.A, Henderson D.A, Henderson D.A, Henderson D.A, Henderson D.A, Henderson D.A, Henderson D.A, Henderson D.A, Henderson D.A, Jungalwalla N.K, Mahler H, Maltseva N, Mani C, Naraindas Harish, Payne A.M.H, Pifer John M, Sanjoy Bhattacharya, Singh Mahendra   +33 more
core   +2 more sources

Rethinking Smallpox [PDF]

Clinical Infectious Diseases, 2004
The potential consequences of a competently executed smallpox attack have not been adequately considered by policy makers. The possibility of release of an aerosolized and/or bioengineered virus must be anticipated and planned for. The transmission and infectivity of variola virus are examined.
Martin M, Weiss, Peter D, Weiss, Glenn, Mathisen, Phyllis, Guze   +3 more
openaire   +2 more sources

Patterns of smallpox mortality in London, England, over three centuries.

PLoS Biology, 2020
Smallpox is unique among infectious diseases in the degree to which it devastated human populations, its long history of control interventions, and the fact that it has been successfully eradicated.
Olga Krylova, David J D Earn
doaj   +1 more source

Immunogenicity and safety of three consecutive production lots of the non replicating smallpox vaccine MVA: A randomised, double blind, placebo controlled phase III trial [PDF]

, 2018
BackgroundModified Vaccinia Ankara (MVA) is a live, viral vaccine under advanced development as a non-replicating smallpox vaccine. A randomised, double-blind, placebo-controlled phase III clinical trial was conducted to demonstrate the humoral ...
Chaplin, Paul, De Carli, Sonja, Kreusel, Christian, Lawrence, Steven J, Meyer, Thomas P, Nopora, Katrin, Overton, Edgar Turner, Rosch, Siegfried, Samy, Nathaly, Schnidt, Darja, Wagner, Eva, Weidenthaler, Heinz, Young, Philip   +12 more
core   +3 more sources

Phase-out of smallpox vaccination and the female/male HIV-1 prevalence ratio: an ecological study from Guinea-Bissau

BMJ Open, 2019
Objective In Guinea-Bissau, West Africa, we observed that having a smallpox vaccination scar was associated with lower HIV-1 prevalence, more strongly for women than men.
Marie Villumsen, Peter Aaby, Amabelia Rodrigues, Andreas Rieckmann, Christine Benn, Bo Langhoff Hønge, Signe Sørup, Zacarias Jose da Silva, Hilton Whittle   +8 more
doaj   +1 more source

The role of research in viral disease eradication and elimination programs: Lessons for malaria eradication [PDF]

, 2011
By examining the role research has played in eradication or regional elimination initiatives for three viral diseases-smallpox, poliomyelitis, and measles-we derive nine cross-cutting lessons applicable to malaria eradication.
Breman, JG, de Quadros, CA, Dowdle, WR, Foege, WH, Henderson, DA, John, TJ, Levine, MM   +6 more
core   +1 more source